白杨素生物利用度的影响因素及提高办法研究进展  

Research progress on influencing factors and improving methods of chrysin bioavailability

作　　者：石志群 田贻婷 张朋朋 张洁 谭宏强 景临林 马慧萍 SHI Zhi-qun;TIAN Yi-ting;ZHANG Peng-peng;ZHANG Jie;TAN Hong-qiang;JING Lin-lin;MA Hui-ping(Department of Medicinal Chemistry,School of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000;Department of Pharmacy,The 940th Hospital of Joint Logistics Support Force of the People’s Liberation Army,The Lab of People’s Liberation Army for High Altitude Medicine,Lanzhou 730050)

机构地区：[1]甘肃中医药大学药学院,兰州730000 [2]联勤保障部队第九四〇医院药剂科,全军高原医学重点实验室,兰州730050

出　　处：《中南药学》2022年第6期1379-1384,共6页Central South Pharmacy

基　　金：国家自然科学基金项目(No.81571847);军队后勤科研计划(No.CWH17J010);军队卫勤保障能力创新与生成专项(No.21WQ045)。

摘　　要：白杨素是一种黄酮多酚类化合物,具有抗肿瘤、抗炎、降血脂、抗焦虑、抗抑郁等多种生物活性,然而其体内生物活性受到口服生物利用度等因素的制约,无法更好地发挥其疗效。本文从白杨素在体内的吸收、代谢、外排等角度出发,综述影响其口服生物利用度的因素及提高方法,明确白杨素口服生物利用度的研究方向,为白杨素新药开发奠定基础。Chrysin is a flavonoid polyphenol compound,with various biological activities such as anti-tumor,anti-inflammatory,hypidemic,anti-anxiety,and anti-depression effect.However,it’s in vivo bioactivity is influenced and limited by bioavailability,making it difficult to attain better effects.This paper reviewed factors affecting chrysin oral bioavailability and enhancement strategies by focusing on their absorption,metabolism,and elimination processes in vivo.Based on the above progress,the perspective of chrysin oral bioavailability is put forward,which can provide the basis for chrysin drug development.

关 键 词：白杨素 生物利用度 制剂 结构修饰 研究进展 

分 类 号：R945[医药卫生—微生物与生化药学] R96[医药卫生—药剂学]