神经内分泌和穴位刺激调节免疫及炎症机制研究进展  

Research progress on regulation of neuroendocrine and acupoint stimulation on immunity and inflammation

作　　者：杨虎 符兆英[1] 张正祥[1] 董闪 薛睿阳 马千娇 YANG Hu;FU Zhaoying;ZHANG Zhengxiang;DONG Shan;XUE Ruiyang;MA Qianjiao(College of Medicine,Yan’an University,Yan’an 716000,China)

机构地区：[1]延安大学医学院,陕西延安716000

出　　处：《陕西中医》2022年第7期982-984,F0003,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81760732);陕西省重点研发计划项目(2022SF-393)。

摘　　要：神经系统、内分泌系统与免疫系统之间存在错综复杂的关系。神经内分泌信号对免疫细胞活性和免疫应答起重要的调节作用。促肾上腺皮质激素、内啡肽生长激素、催乳素对免疫细胞活性和免疫应答起刺激性或增强性调节作用,而生长抑素起抑制性调节作用。躯体感觉神经可将刺激信号传导到脑干,然后激活传出迷走神经,抑制炎症反应。肠道神经元通过反射性调节肠道巨噬细胞功能调节炎症反应。血脑屏障通过调节免疫细胞通透性调节自身免疫性疾病的进展。通过电针穴位刺激连接大脑与肾上腺的迷走神经可以减轻机体炎症。There is an intricate relationship between nervous system,endocrine system and immune system.Neuroendocrine signals play an important role in the regulation of immune cell activity and immune response.Adrenocorticotropic hormone,endorphin growth hormone,and prolactin mainly play a stimulatory or enhancing role in regulating immune cell activity and immune response,while somatostatin mainly plays an inhibitory role.Somatosensory nerves send stimulatory signals to the brain stem,which then activate the efferent vagus nerve,which exerts inhibitory regulation of inflammation.Intestinal neurons modulate inflammatory responses by reflexively modulating the function of intestinal macrophages.The blood brain barrier regulates the onset and progression of autoimmune diseases by controlling the permeability of immune cells.Stimulating the vagus nerve,which connects the brain to the adrenal glands,could reduce inflammation.

关 键 词：神经系统 内分泌系统 免疫系统 炎症反应 穴位 电针 

分 类 号：R392[医药卫生—免疫学]