温度响应型淀粉醚/海藻酸钠复合凝胶的制备及其性能  

Preparation and characterization of thermoresponsive starch ether/sodium alginate composite hydrogels

作　　者：庞子健 徐源 姜硕 孙萌 姜谦[1] 孙薇 查晓晗 尚悦 代明允 刘鹰 田野 PANG Zijian;XU Yuan;JIANG Shuo;SUN Meng;JIANG Qian;SUN Wei;ZHA Xiaohan;SHANG Yue;DAI Mingyun;LIU Ying;TIAN Ye(College of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China;Key Laboratory of Environment Controlled Aquaculture (Dalian Ocean University), Dalian 116023, China;College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China)

机构地区：[1]大连海洋大学海洋科技与环境学院,辽宁大连116023 [2]设施渔业教育部重点实验室(大连海洋大学),辽宁大连116023 [3]浙江大学生物系统工程与食品科学学院,浙江杭州310058

出　　处：《大连海洋大学学报》2022年第3期505-512,共8页Journal of Dalian Ocean University

基　　金：国家自然科学基金(31901775,31672673);广东省重点领域研发计划项目(2019B020215001);大连市青年科技之星项目(2021RQ113);设施渔业教育部重点实验室(大连海洋大学)资助项目(202224)。

摘　　要：为制备具有良好温度响应性能的多糖基复合凝胶材料,以2-羟基-3-异丙氧基丙基淀粉醚(HIPS)和海藻酸钠(SA)为原料,乙二醇二缩水甘油醚(EDGE)和CaCl_(2)为混合交联剂,通过交联反应制备温度响应型HIPS/SA复合凝胶,利用傅里叶转换红外光谱(FT-IR)、扫描电镜(SEM)表征凝胶的结构及微观形貌,并分析凝胶的温度响应性能。结果表明:反应温度和反应时间均极显著影响HIPS/SA复合凝胶的溶胀率(P<0.01);制备HIPS/SA复合凝胶的最佳反应条件为质量分数6.5%的HIPS 2 g、质量分数4.5%的SA 2 g、NaOH用量300μL、EDGE用量300μL、反应温度55℃和反应时间3 h,在此条件下,凝胶的溶胀率为44.20;HIPS/SA复合凝胶具有温度响应性能,当温度升高至体积相转变温度(VPTT)34.9℃时,复合凝胶的溶胀率急剧下降。本研究中制备的具有优异温度响应性能的淀粉醚/海藻酸钠复合凝胶功能材料,可为功能材料在药物缓释、分离工程等领域的应用提供新的途径。A thermoresponsive hydrogel composed of 2-hydroxy-3-isopropoxypropyl starch(HIPS)and sodium alginate(SA)was synthesized via cross-linking with hybrid crosslinkers including ethylene glycol diglycidyl ether(EDGE)and calcium chloride(CaCl_(2)).Attenuated total reflection infrared spectroscopy(FT-IR)was used to confirm the occurrence of crosslinking.The HIPS/SA composite hydrogels were investigated for their porous architecture and thermoresponsive property using scanning electron microscopy(SEM).The reaction temperature and reaction time significantly affected the swelling rate of HIPS/SA composite hydrogels(P<0.01).The optimum HIPS/SA hydrogel synthesis was observed under conditions of HIPS concentration of 6.5%(2 g),SA concentration of 4.5%(2 g),NaOH of 300μL,EDGE of 300μL,reaction temperature of 55℃and reaction period of 3 h,with the hydrogel swelling ratio of 44.20 under above conditions.It was found that the HIPS/SA hydrogel possessed desirable thermoresponsive property,and the swelling rate(SR)of hydrogel was sharply decreased when the temperature was higher than volume phase transition temperature(VPTT)34.9℃.The HIPS/SA hydrogel with thermoresponsive properties synthesised in this study can provide a new method for the application in the fields of drug delivery and separation engineering.

关 键 词：海藻酸钠 淀粉醚 凝胶 温度响应 

分 类 号：S914[农业科学—水产科学] P734.5[天文地球—海洋化学]