外泌体在肺移植排斥反应中的作用研究进展  

Research progress on the role of exosome in rejection after lung transplantation

作　　者：蒋冠宇 陈思远 徐永瑞 郑明峰 毛文君 Jiang Guanyu;Chen Siyuan;Xu Yongrui;Zheng Mingfeng;Mao Wenjun(Department of Thoracic Surgery,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学附属无锡人民医院胸外科,江苏无锡214023

出　　处：《器官移植》2022年第4期530-536,共7页Organ Transplantation

基　　金：江苏省自然科学基金青年项目(BK20210068)。

摘　　要：肺移植术后排斥反应包括急性排斥反应(AR)和以慢性移植肺功能障碍(CLAD)为主要表现的慢性排斥反应,是影响同种异体移植物长期存活的主要因素。外泌体是真核生物细胞间通讯的一种细胞外纳米囊泡,可以携带复杂生物学信息,参与各种生理、病理过程,已成为排斥反应中的重要免疫介质,通过多种途径调控排斥反应的发生发展,在排斥反应的监测和治疗中亦发挥着关键作用。本文就肺移植术后排斥反应的类型、外泌体调控排斥反应的机制、外泌体作为生物标志物及其在排斥反应治疗中的应用做一综述,旨在为肺移植术后排斥反应的综合诊治提供新的方向。Rejection after lung transplantation,including acute rejection(AR)and chronic rejection manifested with chronic lung allograft dysfunction(CLAD),is the main factor affecting the long-term survival of allografts.Exosome,a type of extracellular nanovesicle for intercellular communication among eukaryotic cells,could carry complex biological information and participate in various physiological and pathological processes.Exosome has become a critical immune medium in rejection,regulates the incidence and development of rejection through multiple pathways,and also plays a key role in the monitoring and management of rejection.In this article,the type of rejection after lung transplantation,the mechanism underlying the role of exosome in regulating rejection,exosome acting as biomarkers and the application in rejection treatment were reviewed,aiming to provide a novel direction for comprehensive diagnosis and treatment of rejection following lung transplantation.

关 键 词：肺移植 外泌体 慢性移植肺功能障碍(CLAD) 急性细胞介导排斥反应(ACR) 限制性移植物综合征(RAS) 闭塞性细支气管炎综合征(BOS) 主要组织相容性复合体(MHC) 供者特异性抗体(DSA) 

分 类 号：R617[医药卫生—外科学] R563[医药卫生—临床医学]