AMI并发心力衰竭患者BDNF、CA-125、cTnI水平变化及影响因素  

Changes and influencing factors of BDNF,CA-125,cTnI levels in patients with AMI complicated by heart failure

作　　者：贾立娟[1] 侯月柳 于芳 王涛 JIA Lijuan;HOU Yueliu;YU Fang;WANG Tao(Department of Physical Examination,Baoding Second Central Hospital,Baoding,Hebei,China,072750;Department of Emergency,Baoding Second Central Hospital,Baoding,Hebei,China,072750;Rongcheng County People's Hospital,Baoding,Hebei,China,071700;Department of Internal Medicine,Fengning Manchu Autonomous County Hospital of Traditional Chinese Medicine,Chengde,Hebei,China,068350)

机构地区：[1]保定市第二中心医院体检科,河北保定072750 [2]保定市第二中心医院急诊科,河北保定072750 [3]容城县人民医院,河北保定071700 [4]河北承德丰宁满族自治县中医院内三科,河北承德068350

出　　处：《分子诊断与治疗杂志》2022年第6期912-915,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省科技攻关计划项目(2019013015)。

摘　　要：目的 研究急性心肌梗死(AMI)并发心力衰竭患者脑源性神经营养因子(BDNF)、糖类抗原-125(CA-125)、心肌肌钙蛋白I(cTnI)水平变化及影响因素。方法 分析2019年1月至2021年1月于保定市第二中心医院治疗的128例AMI患者的临床资料,根据有无合并心力衰竭将患者分为合并组(n=42)、未合并组(n=86),另选取43名同期行健康体检者作为健康组。比较各组BDNF、cTnI和CA-125水平,分析影响AMI患者并发心力衰竭的相关危险因素。结果 BDNF、cTnI以及CA-125水平:合并组>未合并组>健康组(P<0.05)。年龄、性别、高血压、血脂、体重指数等为非影响AMI患者并发心力衰竭的单因素(P>0.05),BDNF、cTnI以及CA-125为影响AMI患者并发心力衰竭的单因素(P<0.05)。多因素Logistic回归模型分析结果显示,BDNF、cTnI以及CA-125为影响AMI患者并发心力衰竭的独立危险因素(P<0.05)。结果 BDNF、CA-125、cTnI作为影响AMI患者并发心力衰竭的独立危险因素,在不同人群之间存在明显差异,临床可根据其水平变化作为判断AMI患者并发心力衰竭的参考依据之一。Objective To study the changes and influencing factors of brain-drived neurotrophic factor(BDNF),carbohydrate antigen-125(CA-125)and cardiac troponin I(cTnI)levels in patients with acute myocardial infarction(AMI)complicated by heart failure. Methods The clinical data of 128 patients with AMI treated in Baoding Second Central Hospital from January 2019 to January 2021 were analyzed. The patients were divided into the combined group(n=42) and the uncombined group(n=86) according to whether the patients had complicated heart failure. Another 43 patients who had physical examination at the same time period were selected as the healthy group. The levels of BDNF,cTnI and CA-125 in each group were compared,and the related risk factors affecting AMI patients complicated with heart failure were analyzed. Results The levels of BDNF,c TnI and CA-125:combined group > uncombined group > healthy group(P<0.05). Age,gender,hypertension,blood lipids,body mass index was not single factors that affected heart failure of AMI patients(P>0.05). BDNF,cTnI and CA-125 were single factors that affected heart failure of AMI patients(P<0.05). According to the results of multivariate logistic regression modelanalysis,BDNF,c Tn I and CA-125 were independent risk factors that affected heart failure of AMI patients(P<0.05). Conclusion BDNF,CA-125,and c Tn I are independent risk factors that affect heart failure of AMI patients,there are significant differences between different populations. Clinically,the changes in their levels can be used as one of the references for judging AMI patients complicated with heart failure.

关 键 词：AMI并发心力衰竭 BDNF CA-125 CTNI 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]