Elastin、LRP-1、VIP在盆腔脏器脱垂患者中的表达及检测价值  

Expression and detection value of Elastin,LRP-1 and VIP in patients with pelvic organ prolapse

作　　者：吴明秀[1,2] 李秋萍 刘巍 WU Mingxiu;LI Qiuping;LIU Wei(Department of Obstetrics and Gynecology,Dongguan People's Hospital,Dongguan,Guangdong,China,523000;Department of Obstetrics and Gynecology,Dongguan Xiegang Hospital,Dongguan,Guangdong,China,523000)

机构地区：[1]东莞市人民医院妇产科,广东东莞523000 [2]东莞市谢岗医院妇产科,广东东莞523000

出　　处：《分子诊断与治疗杂志》2022年第6期983-986,991,共5页Journal of Molecular Diagnostics and Therapy

基　　金：东莞市社会科技发展(重点)项目(201950715033171)。

摘　　要：目的探讨弹性蛋白(Elastin)、低密度脂蛋白相关受体-1(LRP-1)、血管活性肠肽(VIP)在盆腔脏器脱垂(POP)患者中的表达意义。方法选取南方医科大学附属东莞医院妇产科POP患者80例作为观察组,另选取同期因妇科良性病变而行子宫和双附件切除且无POP患者40例作为对照组。对比两组、不同盆腔器官脱垂定量分期法(POP-Q)分级患者阴道前壁组织中Elastin、LRP-1、VIP蛋白、胶原纤维、弹性纤维表达情况,评价Elastin、LRP-1、VIP蛋白与胶原纤维、弹性纤维、POP-Q分级相关性。结果观察组阴道前壁组织中Elastin、LRP-1、VIP蛋白表达强度、表达量低于对照组,差异有统计学意义(u=6.574、3.421、6.784,t=15.879、6.767、15.955,P均<0.05);观察组中胶原纤维、弹性纤维表达少于对照组,POP-Q分级4级患者Elastin、LRP-1、VIP蛋白表达强度、表达量低于3级患者,差异有统计学意义(P<0.05);Elastin、LRP-1、VIP蛋白与胶原纤维、弹性纤维呈正相关,与POP-Q分级呈负相关(P<0.05)。结论Elastin、LRP-1、VIP在POP患者阴道前壁组织中呈明显低表达,与胶原纤维、弹性纤维、病情程度显著相关,增强其活性可能是防治POP的潜在疗法。Objective To investigate the expressions of elastin(Elastin),low-density lipoproteinrelated receptor-1(LRP-1)and vasoactive intestinal peptide(VIP)in patients with pelvic organ prolapse(POP).Methods A total of 80 patients with POP in the Department of Obstetrics and Gynecology,Dongguan Hospital Affiliated to Southern Medical University were selected as the observation group,and 40 patients without POP who underwent hysterectomy and double adnexectomy due to benign gynecological lesions during the same period were selected as the control group.The expressions of Elastin,LRP-1,VIP protein,collagen fibers and elastic fibers in the anterior vaginal wall tissue of patients with different pelvic organ prolapse quantitative staging(POP-Q)grades were compared between the two groups.The correlation between Elastin,LRP-1,VIP protein and collagen fiber,elastic fiber and POP-Q grade was evaluated.Results The expression intensity and expression level of Elastin,LRP-1 and VIP proteins in the anterior vaginal wall tissue in the observation group were lower than those in the control group,and the differences were statistically significant(u=6.574,3.421,6.784,t=15.879,6.767,15.955,P<0.05).The expression of collagen fibers and elasticfibers in the observation group was lower than that in the control group,and the expression intensity and expression of Elastin,LRP-1,and VIP proteins in patients with POP-Q grade 4 were lower than those in patients with grade 3(P<0.05).Elastin,LRP-1 and VIP proteins were positively correlated with collagen fibers and elastic fibers,and negatively correlated with POP-Q grades(P<0.05).Conclusion Elastin,LRP-1 and VIP are significantly low expressed in the anterior vaginal tissue of patients with POP,and are significantly related to collagen fibers,elastic fibers,and disease severity.Enhancing their activities may be a potential therapy for the prevention and treatment of POP.

关 键 词：盆腔脏器脱垂 弹性蛋白 低密度脂蛋白相关受体-1 血管活性肠肽 盆腔器官脱垂定量分期法分级 

分 类 号：R711.2[医药卫生—妇产科学]