血清EGF,sCD163及IL-6在新生儿肺炎患儿中的表达及临床价值  

Expression and clinical value of serum EGF,sCD163 and IL-6 in children with neonatal pneumonia

作　　者：曹哲 常会娟 李柯[1] 于映映 杨祯 CAO Zhe;CHANG Huijuan;LI Ke;YU Yingying;YANG Zhen(Zhengzhou University Children's Hospital,Henan Children's Hospital,Zhengzhou Children's Hospital Outpatient Department,Zhengzhou,Henan,China,450000;Department of Respiratory Medicine,Zhengzhou Children's Hospital,Henan Children's Hospital,Affiliated Children's Hospital of Zhengzhou University,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院门诊部,河南郑州450000 [2]郑州大学附属儿童医院河南省儿童医院郑州儿童医院呼吸内科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2022年第6期1008-1011,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(LHGJ20190901)。

摘　　要：目的 探究血清表皮生长因子(EGF)、可溶性血红蛋白道夫受体(sCD163)及白细胞介素-6(IL-6)在新生儿肺炎患儿中的表达及临床价值。方法 选取2020年1月至2021年12月期间于郑州大学附属儿童医院河南省儿童医院门诊部接受治疗的新生儿肺炎患儿共计57例作为观察组,选取同期健康新生儿57例作为对照组,检测并比较两组的血清EGF,sCD163及IL-6水平。将观察组患儿按照病情严重程度分为轻症组(37例)和重症组(20例),检测并比较两组患儿的血清EGF,sCD163及IL-6水平。探讨血清EGF,sCD163及IL-6水平在新生儿肺炎患儿中的表达并进行分析。采用ROC曲线分析血清EGF,sCD163及IL-6水平对新生儿肺炎患儿疾病严重程度的预测价值。结果 观察组患儿的血清EGF,sCD163及IL-6水平显著高于对照组新生儿,差异有统计学意义(P<0.05)。重症组患儿的血清EGF,sCD163及IL-6水平显著高于轻症组患儿,差异有统计学意义(P<0.05)。患儿血清EGF,sCD163及IL-6水平与肺炎患儿疾病严重程度呈正比(P<0.05)。ROC曲线分析显示,血清EGF,sCD163及IL-6水平对新生儿肺炎患儿疾病严重程度均具有预测价值(P<0.05)。结论 血清EGF,sCD163及IL-6水平在健康新生儿以及新生儿肺炎患儿中有差异性,在不同病情的新生儿肺炎患儿也具有差异性,测定血清EGF,sCD163及IL-6水可作为判断新生儿有无肺炎以及肺炎病情变化的参考指标。Objective To investigate serum epidermal growth factor(EGF),soluble hemoglobin Doffer receptor(sCD163)and the expression and clinical value of interleukin-6(IL-6)in children with neonatal pneumonia. Methods A total of 57 children with neonatal pneumonia who were treated in the Outpatient Department of Henan Provincial Children’s Hospital of Zhengzhou University Children’s Hospital from January 2020 to December 2021 were selected as the observation group. Fifty-seven healthy children who underwent physical examination in the outpatient department were used as the control group,and the serum levels of EGF,sCD163 and IL-6 were detected and compared between the two groups. The 57 children in the observation group were divided into a mild group(37 cases)and a severe group(20 cases)according to the severity of the disease,and the serum levels of EGF,sCD163 and IL-6 were detected and compared betweenthe two groups. The ROC curve was used to analyze the predictive value of serum EGF,sCD163 and IL-6 levels on the severity of disease in children with neonatal pneumonia. Results The serum levels of EGF,sCD163 and IL-6 in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05). The serum levels of EGF,sCD163 and IL-6 in the severe group were significantly higher than those in the mild group,and the difference was statistically significant(P<0.05). The serum EGF,sCD163 and IL-6 levels were positively proportional to the severity of the disease in children with pneumonia(P<0.05). ROC curve analysis showed that serum EGF,sCD163 and IL-6 levels had predictive value for disease severity in children with neonatal pneumonia(P<0.05). Conclusion The levels of serum EGF,sCD163 and IL-6 are different in healthy children and children with neonatal pneumonia,and in children with neonatal pneumonia with different conditions. Determination of serum EGF,sCD163 and IL-6 levels can be used as a reference indicator for judging whether neonates have pneumonia a

关 键 词：新生儿 肺炎 表皮生长因子 可溶性血红蛋白道夫受体 白细胞介素-6 

分 类 号：R722.135[医药卫生—儿科]