自拟活血通络汤治疗不稳定型心绞痛患者的效果  

Effects of self-made Huoxue Tongluo decoction on patients with unstable angina pectoris

作　　者：魏艾贞 WEI Aizhen(Department of Traditional Chinese Medicine of Hongda Hospital Affiliated To Jiamusi University,Jiamusi 154000 Heilongjiang,China)

机构地区：[1]佳木斯大学宏大医院中医内科,黑龙江佳木斯154000

出　　处：《中国民康医学》2022年第11期87-90,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察自拟活血通络汤治疗不稳定型心绞痛(UAP)患者的效果。方法:回顾性分析2019年1月至2021年1月该院收治的112例心血瘀阻型UAP患者的临床资料,按照治疗方法不同分为对照组和观察组各56例。对照组采用西医常规治疗,观察组在对照组基础上采用自拟活血通络汤治疗,比较两组临床疗效、治疗前后心绞痛发作情况(发作次数、发作时长、硝酸甘油用量)、斑块稳定参数(最大斑块厚度、斑块内增强强度、达峰时间)水平、C反应蛋白(CRP)水平、心肌损伤指标[心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)]水平和不良反应发生率。结果:观察组治疗总有效率为98.21%(55/56),高于对照组的83.93%(47/56),差异有统计学意义(P<0.05);治疗后,观察组心绞痛发作次数和硝酸甘油用量均少于对照组,发作时长短于对照组,差异有统计学意义(P<0.05);观察组最大斑块厚度、斑块内增强强度均小于对照组,达峰时间短于对照组,差异有统计学意义(P<0.05);观察组血清CRP、cTnI、CK-MB水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在西医常规治疗基础上采用自拟活血通络汤治疗UAP患者可提高治疗总有效率,减少心绞痛发作次数和硝酸甘油用量,缩短发作时长,降低斑块稳定参数水平和心肌损伤指标水平,效果优于单纯西医常规治疗。Objective: To observe effects of self-made Huoxue Tongluo decoction on patients with unstable angina pectoris(UAP).Methods: The clinical data of 112 patients with UAP of heart blood stasis type admitted to our hospital from January 2019 to January 2021 were retrospectively analyzed. According to different treatment methods, they were divided into control group and observation group, 56 cases in each. The control group was treated with conventional western medicine, while the observation group was treated with self-made Huoxue Tongluo decoction on the basis of that of the control group. The clinical efficacy, the angina attacks before and after the treatment [number of angina attacks, attack duration, Nitroglycerin dosage], the plaque stability parameter levels [maximum plaque thickness, intraplaque enhancement intensity, time to peak], the inflammatory factor [C Reactive protein(CRP)] level, the myocardial injury indicator levels [cardiac troponin I(cTnI), creatine kinase isoenzyme MB(CK-MB)] and incidence of adverse reactions were compared between the two groups. Results: The total effective rate of treatment in the observation group was 98.21%(55/56), which was higher than that the control group of 83.93%(47/56), and the difference was statistically significant(P<0.05).After the treatment, the number of angina attacks and the dosage of Nitroglycerin in the observation group were less than those in the control group;the duration of attacks was shorter than that in the control group;and the differences were statistically significant(P<0.05). The maximum plaque thickness and the intraplaque enhancement intensity of the observation group were smaller than those of the control group;the time to peak was shorter than that of the control group;and the differences were statistically significant(P<0.05). The levels of serum CRP, cTnI and CK-MB in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). However, there was no significant difference in th

关 键 词：自拟活血通络汤 硝酸甘油 心血瘀阻型 不稳定型心绞痛 C反应蛋白 肌酸激酶同工酶 不良反应 

分 类 号：R541[医药卫生—心血管疾病]