血浆、浓缩红细胞不同比例输注应用于大量输血患者的效果比较  

Comparison of effects of transfusion of plasma and packed red blood cells in different ratios in patients with massive transfusion

作　　者：鲁潇 史芳瑜 李雅钦 LU Xiao;SHI Fangyu;LI Yaqin(Nanyang Central Hospital,Outpatient Department,Nanyang 473000 Henan,China;Nanyang Central Hospital,Comprehensive Treatment Room,Nanyang 473000 Henan,China;Oncology Laboratory of Nanyang First People’s Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市中心医院门诊,河南南阳473000 [2]南阳市中心医院综合治疗室,河南南阳473000 [3]南阳市第一人民医院肿瘤实验室,河南南阳473000

出　　处：《中国民康医学》2022年第11期149-152,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较血浆、浓缩红细胞不同比例输注应用于大量输血患者的效果。方法:选取92例大量输血患者为研究对象,按照随机数字表法分为A组、B组、C组各31例。A组采用血浆、浓缩红细胞1∶1输注,B组采用血浆、浓缩红细胞1∶2输注,C组采用血浆、浓缩红细胞1∶3输注,比较三组凝血功能指标[活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)]水平、炎性因子[白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]水平、下床活动时间和住院时间。结果:输血后,A组APTT、PT水平低于B组和C组,且B组低于C组,差异均有统计学意义(P<0.05);A组IL-10、TNF-α水平低于B组和C组,且B组低于C组,差异均有统计学意义(P<0.05);A组下床活动时间、住院时间短于B组、C组,且B组短于C组,差异有统计学意义(P<0.05)。结论:血浆、浓缩红细胞1∶1输注应用于大量输血患者可降低凝血功能指标水平和炎性因子水平,以及缩短下床活动时间和住院时间,效果优于血浆、浓缩红细胞1∶2输注和血浆、浓缩红细胞1∶3输注效果,且血浆、浓缩红细胞1∶2输注效果优于血浆、浓缩红细胞1∶3输注效果。Objective: To compare effects of transfusion of plasma and packed red blood cells in different ratios in patients with massive transfusion. Methods: 92 patients with massive transfusion were selected as the research objects and were divided into group A(n=31), group B(n=31) and group C(n=31) according to the random number table method. Group A was infused with plasma and packed red blood cells in 1:1, group B was infused with plasma and packed red blood cells in 1:2, and group C was infused with plasma and packed red blood cells in 1:3. The levels of coagulation function indexes [activated partial thromboplastin time(APTT), prothrombin time(PT)], the inflammatory factor levels [interleukin-10(IL-10), tumor necrosis factor alpha(TNF-α)], the out-of-bed time and the hospitalization time were compared among the three groups. Results: After blood transfusion, the levels of APTT and PT in group A were lower than those in groups B and C;those in group B were lower than those in group C;and the differences were statistically significant(P<0.05). The levels of IL-10 and TNF-α in group A were lower than those in groups B and C;those in group B were lower than those in group C;the differences were statistically significant(P<0.05). Further, the out-of-bed time and the hospitalization time in group A were shorter than those in group B and group C;those in group B were shorter than those in group C;and the differences were statistically significant(P<0.05). Conclusions: The 1:1 infusion of plasma and packed red blood cells in the patients with massive transfusion can reduce the levels of coagulation function indexes and the inflammatory factors and s shorten the out-of-bed time and the hospitalization time, and its effects are better than 1:2 infusion of plasma and packed red blood cells. Further, 1:2 and 1:3 infusion of plasma and packed red blood cells are superior to 1:3 infusion of plasma and packed red blood cells.

关 键 词：大量输血 血浆 浓缩红细胞 比例 输注 凝血功能 炎性因子 

分 类 号：R457.1[医药卫生—治疗学]