85岁以上非痴呆老人保护性因素分析  

Clinical characteristics of non-demented elderly aged 85 years and older

作　　者：许春燕 邱国真 郭启雯 陈淳淳 朱飞奇 Xu Chunyan;Qiu Guozhen;Guo Qiwen;Chen Chunchun;Zhu Feiqi(Cognitive Impairment Ward of Neurology Department,The Hospital of Luohu District,Shenzhen City,Guangdong Province,518001,China)

机构地区：[1]深圳罗湖区人民医院神经内科认知障碍病区,广东深圳518001

出　　处：《阿尔茨海默病及相关病杂志》2022年第2期143-147,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：深圳市罗湖区软科学研究计划项目“85岁以上老人痴呆保护因素分析”(LX20210708);深圳市科创委重点项目“AD前期和患者健康管理大数据构建及其预测预警模式研究”(JCYJ20200109143431341);深圳市罗湖区人民医院神经内科深圳市三名工程“瑞典卡洛琳斯卡医学院NVS系Bengt Winblad阿尔茨海默病团队”(SZSM201801014)。

摘　　要：目的:探讨85岁以上非痴呆老人保护性因素。方法:采用横断面调查的方法,收集高龄非痴呆组老人(年龄≥85岁)及阿尔茨海默病组患者的人口学资料、既往病史及家族史、神经心理量表、人体成份分析及血液检测指标(血常规、空腹血糖、糖化血红蛋白、血脂、肝肾功能、尿酸),并进行统计分析。结果:完成调查者共有63例,其中高龄非痴呆组29例(年龄87.55±2.95岁);阿尔茨海默病组34例(年龄75.18±7.23岁)。人口学及既往史、家族史:两组的性别、受教育年限、糖尿病病史、脑外伤史、癫痫史、全麻手术史比较均无统计学意义(P>0.05);两组高血压患病率对比有统计学意义(高龄非痴呆组68.96%VS阿尔茨海默病组38.24%,P=0.04);两组痴呆家族史比较有统计学意义(P=0.01)。两组认知功能对比有统计学意义(高龄非痴呆组MMSE 23.49±3.31分VS阿尔茨海默病组MMSE 12.71±7.30分,P=0.001)。人体成份分析结果:两组的身高、体重、BMI、脂肪量、水分量、肌肉量、去脂体重、内脏脂肪、基础代谢率比较均无统计学意义(P>0.05);两组的骨量比较有统计学意义(P<0.05)。血常规、血生化分析结果:两组的白细胞、红细胞、血红蛋白、血小板、糖化血红蛋白、总胆固醇、低密度、甘油三酯、AST、ALT、白蛋白、球蛋白、直接胆红素、间接胆红素、尿素氮、肌酐、尿酸比较均无统计学意义(P>0.05);两组的空腹血糖、高密度、总蛋白、总胆红素的差异有统计学意义(P<0.05)。结论:85岁及以上非痴呆组老人有较高的高血压患病率,均无痴呆家族史,BMI多处于超重范围,有较低的空腹血糖、高密度脂蛋白、总胆红素,有较高的血清总蛋白。Objective: To explore the clinical characteristics of non-dementia elderly aged 85 years and older. Methods: The data of demographic, medical history and family history, neuropsychological scale, body composition and blood test indexes(blood routine,fasting blood glucose, blood lipids, liver and kidney function, uric acid) collected from the elderly non-dementia Group(age ≥ 85 years) and Alzheimer’s Disease Groupwere analyzed. Results: 63 cases were divided into non-dementia group(n=29, average age 87.55 ± 2.95 years) and AD group(n=34, average age 75.18 ± 7.23 years). Demographic and past history, family history: There was no significant difference between the two group in sex, years of education, history of diabetes, history of brain injury, history of epilepsy, history of General Anesthesia(P >0.05);The prevalence of hypertension in the two group statistically significant(68.96% VS 38.24%, P = 0.04), the family history of dementia was statistically significant(P = 0.01). There was significant difference in cognitive function between the two group(MMSE 23.49 ± 3.31 VS 12.71 ± 7.30, P= 0.001). The results of body composition analysis showed that there was no significant difference in height, weight, BMI, fat,water content, muscle mass, lean body weight, visceral fat and metabolic rate between the two group(P >0.05),The bone mass of the two group statistically significant(P<0.05). Results: of blood routine examination and blood biochemical analysis: white blood cells, red blood cells,hemoglobin, platelets, Hba1c, total cholesterol, low density, triglyceride, AST, ALT, albumin, Globulin, direct Bilirubin, indirect Bilirubin, urea,creatinine and uric acid were no significant differences between the two group(P >0.05);fasting blood glucose, high density, total protein and total bilirubin were significant differences between the two group(P<0.05). Conclusion: The non-dementia group aged 85 years and older has higher prevalence of hypertension;no family history of dementia;BMI in overweight range;lower fasting

关 键 词：高龄老人 痴呆 阿尔茨海默病 人体成分 血糖 白蛋白 

分 类 号：R421.02[医药卫生—临床医学]