原发性肾小球肾炎与妊娠的研究进展  

Research advances of primary glomerulonephritis and pregnancy

作　　者：王楠[1] 杨涛 郝秋发 江蓓[1] 胡昭[1] Wang Nan;Yang Tao;Hao Qiu-fa;J iang Bei;Hu Zhao(Department of Nephrology,Qilu Hospital of Shandong University,Jinan 250012,China;Medical Management Service Center of Shandong Health Commission,J inan 250012,China)

机构地区：[1]山东大学齐鲁医院肾内科,济南250012 [2]山东省卫生健康委员会医疗管理服务中心,济南250012

出　　处：《临床肾脏病杂志》2022年第6期502-506,共5页Journal Of Clinical Nephrology

基　　金：山东省重点研发计划项目(2017GSF21116)。

摘　　要：随着原发性肾小球肾炎发病率的增加和女性高龄妊娠,妊娠期肾脏疾病的管理成为肾内科和妇产科医师共同的难题。因为妊娠期肾脏生理需求的增加,患有原发性肾小球肾炎的妇女在妊娠期间面临若干挑战:药物的潜在致畸性、先兆子痫和早产等并发症的风险增加、肾脏疾病的进展等。如何评估原发性肾小球肾炎患者的妊娠时机并对妊娠过程进行监测和管理是临床医生和患者共同关心的问题。本文总结了近年来有关原发性肾小球肾炎合并妊娠的最新研究进展:原发性肾小球肾炎患者妊娠结局的危险因素、妊娠对原发性肾小球肾炎患者肾脏进展的影响、不同类型原发性肾小球肾炎合并妊娠的研究结果及肾脏病相关药物妊娠期的应用。With a rising incidence of primary glomerulonephritis(PGN)and more women pursuing pregnancy at more advanced ages,management of kidney disease in pregnancy has become a common problem for both nephrologists and obstetricians.Women with PGN face several challenges during pregnancy due to their elevated physiologic demands on kidney,such as potential teratogenicity of medications,higher risks of preeclampsia and preterm delivery and progression of kidney disease.How to evaluate the timing of pregnancy in PGN women,monitor and manage the course of pregnancy have remained common concerns for both clinicians and patients.This review summarized the latest findings of PGN women during pregnancy.The topics included risk factors for pregnancy outcomes in PGN,effect of pregnancy on progression of renal disease,different subtypes and drug dosing during pregnancy.

关 键 词：原发性肾小球肾炎 妊娠 IGA肾病 膜性肾病 局灶性节段性肾小球硬化症 

分 类 号：R692.31[医药卫生—泌尿科学] R714.258[医药卫生—外科学]