热分析技术在药物共晶研究中的应用  

Application of Thermal Analysis Techniques in Drug Cocrystals

作　　者：王丽[1] 袁鹏辉 杨德智[1] 张丽[1] 吕扬[1] WANG Li;YUAN Penghui;YANG Dezhi;ZHANG Li;LYU Yang(Beijing City Key Lab.of Polymorphic Drugs,Center of Pharmaceutical Polymorphs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050)

机构地区：[1]北京协和医学院&中国医学科学院药物研究所药物晶型研究中心,晶型药物研究北京市重点实验室,北京100050

出　　处：《中国医药工业杂志》2022年第3期290-298,共9页Chinese Journal of Pharmaceuticals

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费(2021-RW350-001);国家重点研发计划(2016YFC1000901)。

摘　　要：药物共晶一般是活性药物成分和适当的共晶形成物通过非共价键结合堆积形成的多组分药物体系。通过形成共晶,可有效改善固体化学药物的溶解度、稳定性等理化性质,进而提高其生物利用度,目前已成为晶型药物研究领域的热点。热分析技术是指在程序控温下,观察记录被测物质的热力学或物理参数随温度变化关系的一类技术,在药物研发和质量控制方面均发挥着重要作用。热分析技术作为有效分析表征方法在药物共晶筛选中已被广泛应用,同时应用各种热分析技术可对药物共晶的理化性质与热力学行为进行深入研究。本研究综述了近年来应用各种热分析技术在药物共晶研究中取得的研究进展,以期为今后热分析技术在药物共晶研究中的应用提供参考。Drug cocrystals generally refer to the multi-component drug system composed of active pharmaceutical ingredients and cocrystal formers,which are bound by non-covalent bonds.The formation of cocrystal can effectively improve the physicochemical properties of solid chemical drugs such as solubility and stability,and thus enhance their bioavailability,which has become a hot spot in the field of crystalline drug research.Thermal analysis techniques are a class of techniques that observe and record the temperature-dependent thermodynamic or physical parameters of a substance under a controlled temperature program,and play an important role in drug development and quality control.Thermal analysis techniques have been widely used as effective analytical characterization methods in the screening of drug cocrystal,and the application of various thermal analysis techniques enables in-depth studies of the physicochemical properties and thermodynamic behaviors of drug cocrystals.In order to provide some references for the application of thermal analysis techniques in the study of drug cocrystals,the recent progress in the application of various thermal analysis techniques in research of drug cocrystals is reviewed in this paper.

关 键 词：药物共晶 热分析技术 联用技术 

分 类 号：R917[医药卫生—药物分析学]