肿瘤坏死因子-α在慢性炎症与肿瘤发生中的作用  

The role of tumor necrosis factor-alpha in chronic inflammation and tumorigenesis

作　　者：马玉 李研 骆亚莉 王碧雯[1] 周啸天 周世琴 周雯 MA Yu;LI Yan;LUO Ya-li;WANG Bi-wen;ZHOU Xiao-tian;ZHOU Shi-qing;ZHOU Wen(Provincial Key Laboratory of Molecular Medicine and Traditional Chinese Medicine for the Prevention and Treatment of Major Diseases in Colleges and Universities of Gansu Province,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Key Laboratory of Dunhuang Medicine and Transformation,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室,甘肃兰州730000 [2]甘肃中医药大学敦煌医学与转化省部共建教育部重点实验室,甘肃兰州730000

出　　处：《中国临床药理学杂志》2022年第12期1419-1423,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81760804);甘肃省中医药研究中心2019-2020年度开放课题基金资助项目(ZYFY-2019-006);甘肃省2020年度第十批省级科技计划基金资助项目(20JR10RA321)。

摘　　要：炎症与肿瘤关系密切,肿瘤坏死因子α(TNF-α)是参与炎症的主要炎性细胞因子之一,在各种慢性炎症性疾病及肿瘤环境中高表达。TNF-α可诱导其他炎性因子释放放大炎症反应,还可通过释放氧氮介质直接诱导上皮细胞癌变促进肿瘤发生。此外TNF-α还可以通过激活NF-κB等炎症通路促进肿瘤细胞增殖,TNF-α上调血管内皮生长因子表达,促进肿瘤组织微血管生成,促进肿瘤的发展。TNF-α可通过激活NF-κBp52抑制肿瘤细胞凋亡,且可抑制免疫细胞的抗肿瘤活性从而促进肿瘤细胞的免疫逃逸。基于TNF-α在慢性炎症相关性肿瘤的发生、发展、转移及免疫逃逸等多方面均发挥重要作用,TNF-α可成为抗慢性炎症相关性肿瘤精准医疗的潜力靶点,从多个环节、多条途径来发挥抗肿瘤的作用,目前有多个具有TNF-α抑制药作用的天然产物化合物处于试验阶段。本文重点探讨慢性炎症与肿瘤发生中TNF-α的作用,以期为临床上常见的TNF-α相关慢性炎症所致肿瘤的预防及治疗提供理论基础。Inflammation is considered to be closely related to tumor.Tumor necrosis factor-alpha(TNF-α)as one of the main inflammatory cytokines involved in inflammation it is highly expressed in various chronic inflammatory diseases and tumor environments.TNF-αcan induce the release of other inflammatory factors to amplify the inflammatory response,directly induce epithelial cell carcinogenesis and promote tumorigenesis by releasing oxygen and nitrogen mediators.TNF-αpromotes tumor cell proliferation by activated inflammatory pathways such as NF-κB pathway and others.TNF-αup regulates the expression of vascular endothelial growth factor,increases the angiogenesis of tumor tissue,so it can promote the development of tumor.TNF-αinhibits tumor cell apoptosis by activating NF-κBp52,and reduces the antitumor activity of immune cells,both of them make tumor cells immune escape.Because TNF-αplays an important role in the occurrence,development,metastasis and immune escape of chronic inflammation associated tumor,it can become a potential target for precision medicine against chronic inflammation related tumors,and play an anti-tumor role from multiple nodes and pathways.At present,many natural product compounds with TNF-αinhibitors are under research and development.In this paper we focus on the role of TNF-αin chronic inflammation and tumorigenesis expected to provide a theoretical basis for the prevention and treatment of tumors caused by chronic TNF-αrelated chronic inflammation.

关 键 词：肿瘤坏死因子Α 慢性炎症 肿瘤 

分 类 号：R97[医药卫生—药品]