Construction of nanocarriers based on nucleic acids and their applications in nanobiology delivery systems  

作　　者：Yingshu Guo Xiuping Cao Xiaofei Zheng Sk Jahir Abbas Juan Li Weihong Tan 

机构地区：[1]Shandong Provincial Key Laboratory of Molecular Engineering,School of Chemistry and Chemical Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China [2]School of Chemistry and Chemical Engineering,Linyi University,Linyi 276005,China [3]Institute of Cancer and Basic Medicine,Chinese Academy of Sciences,The Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China [4]Institute of Molecular Medicine,State Key Laboratory of Oncogenes and Related Genes,Renji Hospital,Shanghai Jiao Tong University School of Medicine,College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《National Science Review》2022年第5期177-191,共15页国家科学评论（英文版）

基　　金：supported by the Development Plan of the Youth Innovation Team in Colleges and Universities of Shandong Province(2020KJC003);the Natural Science Foundation of Shandong Province of China(ZR2016JL010);the Key Technology Research and Development Program of Shandong Province(2018GSF118172);the National Natural Science Foundation of China(21575056)。

摘　　要：In recent years,nanocarriers based on nucleic acids have emerged as powerful and novel nanocarriers that are able to meet the demand for cancer-cell-specific targeting.Functional dynamics analysis revealed good bio compatibility,low toxicity and programmable structures,and their advantages include controllable size and modifiability.The development of novel hybrids has focused on the distinct roles of biosensing,drug and gene delivery,vaccine transport,photosensitization,counteracting drug resistance and functioning as carriers and logic gates.This review is divided into three parts:(ⅰ)DNA nanocarriers,(ⅱ)RNA nanocarriers and(ⅲ)DNA/RNA hybrid nanocarriers and their applications in nanobiology delivery systems.We also provide perspectives on possible future directions for growth in this field.

关 键 词：nanocarriers based on nucleic acids BIOSENSING targeted delivery CELL 

分 类 号：R943[医药卫生—药剂学]