职业性铅接触工人体内微量元素含量的Meta分析  

Meta-analysis on the contents of trace elements in workers with occupational exposure to lead

作　　者：张玲 谈思维 邵吉[1] 施燕鹏 苏克文 单晓月 叶海朋[1] Zhang Ling;Tan Siwei;Shao Ji;Shi Yanpeng;Su Kewen;Shan Xiaoyue;Ye Haipeng(Hangzhou Hospital for Prevention and Treatment of Occupational Disease,Department of Sanitation Test,Hangzhou 310014,China)

机构地区：[1]杭州市职业病防治院卫生检测科,杭州310014

出　　处：《中华劳动卫生职业病杂志》2022年第5期347-353,共7页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：杭州市卫生计生科技计划项目(A20210491)。

摘　　要：目的:分析职业性铅接触工人体内微量元素含量的差异。方法:于2021年1月,通过中国期刊全文数据库(CNKI)、万方数据库、维普中文科技期刊数据库(VIP)、PubMed、Web of science和Embase系统检索1990至2020年公开发表的职业性铅接触工人体内微量元素含量的相关文献,对文献进行筛选和资料提取,用《纽卡斯尔-渥太华量表》对纳入文献进行质量评价,将职业性铅接触工人作为接触组,非铅接触人员作为对照组,用Review Manager 5.3软件进行Meta分析,用标准化均数差( SMD)及其95%可信区间作为效应指标。 结果:共纳入20篇文献,质量评分为5~7分。Meta分析结果显示,与对照组比较,接触组工人血锌( SMD=-1.01,95% CI:-1.53,-0.49)、发锌( SMD=-0.17,95% CI:-0.33,-0.01)、发铜( SMD=-0.50,95% CI:-1.01,0)、发铁( SMD=-3.91,95% CI:-5.80,-2.03)和发锰( SMD=-1.09,95% CI:-2.02,-0.15)含量较低,差异均有统计学意义( P<0.05);与对照组比较,接触组工人发钴含量( SMD=1.41,95% CI:0.72,2.10)较高,差异有统计学意义( P<0.05);两组间血铬、血铜、血铁、血锰、血硒和发镍含量差异无统计学意义( P>0.05)。 结论:职业性铅接触工人体内存在微量元素异常。Objective To quantitatively evaluate the content differences of trace elements in workers with occupational exposure to lead.Methods In January 2021,relevant literatures on the contents of trace elements in workers with occupational exposure to lead published from 1990 to 2020 were searched through CNKI,Wanfang,VIP,PubMed,web of science and Embase.Screened and extracted the literatures,and evaluated the quality of the included literatures with Newcastle Ottawa Scale.Meta analysis was performed with Review Manager 5.3 software,and standardized mean difference(SMD)and its 95%confidence interval were used as effect indicators.Results A total of 20 literatures were included,and the quality scores were 5-7.The results of Meta-analysis showed that compared with the control group,the contents of blood zinc(SMD=-1.01,95%CI:-1.53,-0.49),hair zinc(SMD=-0.17,95%CI:-0.33,-0.01),hair copper(SMD=-0.50,95%CI:-1.01,0),hair iron(SMD=-3.91,95%CI:-5.80,-2.03)and hair manganese(SMD=-1.09,95%CI:-2.02,-0.15)in occupational lead exposure group were significantly lower(P<0.05).Compared with the control group,the content of cobalt in hair of occupational lead exposure group(SMD=1.41,95%CI:0.72,2.10)was higher,and the difference was statistically significant(P<0.05).There was no significant difference in the contents of blood chromium,blood copper,blood iron,blood manganese,blood selenium and hair nickel between the two groups(P>0.05).Conclusion Workers with occupational exposure to lead have abnormal trace elements.

关 键 词：铅 职业接触 微量元素 META分析 

分 类 号：R135.11[医药卫生—劳动卫生]