Prevalence of nonalcoholic fatty liver disease and its association with age in patients with type 2 diabetes mellitus  

作　　者：Ryosuke Yamane Kentaro Yoshioka Kazuhiko Hayashi Yuko Shimizu Yuki Ito Komei Matsushita Michiyo Yoshizaki Go Kajikawa Taro Mizutani Atsuko Watarai Kosuke Tachi Hidemi Goto 

机构地区：[1]Department of Gastroenterology and Hepatology,Federation of National Public Service Personnel Mutual Aid Associations Meijo Hospital,Nagoya 460-0001,Aichi,Japan [2]Center for Liver Diseases,Federation of National Public Service Personnel Mutual Aid Associations Meijo Hospital,Nagoya 460-0001,Aichi,Japan [3]Department of Diabetes and Endocrinology,Federation of National Public Service Personnel Mutual Aid Associations Meijo Hospital,Nagoya 460-0001,Aichi,Japan

出　　处：《World Journal of Hepatology》2022年第6期1226-1234,共9页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Type 2 diabetes mellitus(T2DM)is a risk factor for nonalcoholic fatty liver disease(NAFLD).AIM To determine the prevalence and clinical correlates of NAFLD in a large cohort of patients with T2DM.METHODS Four hundred thirty-seven participants with T2DM who consulted at Meijo Hospital from April 2019 to September 2020 and underwent computed tomography(CT)were assessed.The mean age was 74±13 years,and 269 were men.Hepatic attenuation minus splenic attenuation(CTL−S)less than 1 Hounsfield unit was considered fatty liver.NAFLD was defined as fatty liver in the absence of significant alcohol consumption and hepatitis virus infection.A multiple logistic regression was used to assess the independent factors associated with NAFLD.RESULTS NAFLD was identified in 25.2%of the participants.Young age(odds ratio[OR]=−0.945;95%confidence interval[CI]:0.922–0.969),higher hemoglobin levels(OR=1.501,95%CI:1.278–1.764),lower high-density lipoprotein(HDL)cholesterol levels(OR=0.971,95%CI:0.953–0.989),and the absence of dialysis(OR=0.109,95%CI:0.014–0.856)were independent predictors of NAFLD.CONCLUSION NAFLD was detected with CT in 25.2%of the participants.NAFLD was associated with younger age,higher hemoglobin levels,lower HDL cholesterol levels,and an absence of dialysis.

关 键 词：Age Computed tomography DIALYSIS HEMOGLOBIN Nonalcoholic fatty liver disease Type 2 diabetes mellitus 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]