Prostate sclerosing adenopathy:A clinicopathological and immunohistochemical study of twelve patients  

作　　者：Run-Lin Feng Yan-Ping Tao Zhi-Yong Tan Shi Fu Hai-Feng Wang 

机构地区：[1]Department of Pathology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan Province,China [2]Department of Emergency,Kunming Third People's Hospital,Kunming 650000,Yunnan Province,China [3]Department of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan Province,China

出　　处：《World Journal of Clinical Cases》2022年第18期6009-6020,共12页世界临床病例杂志

摘　　要：BACKGROUND Although sclerosing adenopathy of the prostate is a very rare benign disease,an effective differential diagnosis is required.Here,we report the clinicopathological and immunohistochemical morphological features of 12 cases of sclerosing adenopathy of the prostate to improve understanding of the disease.AIM To investigate the clinicopathological features,diagnosis,and immunohistochemical phenotypes that distinguish prostate sclerosing adenopathy from other conditions.METHODS The clinical data,laboratory tests,pathological morphology,and immunohistochemical phenotypes of 12 cases of prostatic sclerosing adenopathy were retrospectively analyzed,and the relevant literature was reviewed.RESULTS All patients were elderly men(mean age,71.7 years;62–83 years).Eleven of them had hematuria,urinary frequency,urinary urgency,difficulty in urination,and serum total prostate-specific antigen values within the normal range.One patient had increased blood pressure.Enlarged prostates with single to multiple calcifying foci were observed.Moreover,prostate tissue hyperplastic changes were observed in all patients.Small follicular hyperplastic nodules without an obvious envelope,with a growth pattern mimicking the infiltration pattern of"prostate adenocarcinoma"were noted.Basal cells expressed AR,CKH,P63,and CK5/6,and myoepithelial markers,such as calponin,S100,and smooth muscle actin.No recurrence or exacerbation of the lesions was observed,except for one case of death due to bladder cancer.CONCLUSION Prostatic sclerosing adenopathy is highly misdiagnosed as prostate adenocarcinoma or other tumor-like lesions.Therefore,it should attract the attention of clinicopathologic researchers.

关 键 词：CLINICOPATHOLOGY IMMUNOHISTOCHEMISTRY Prostate disease Sclerosing adenopathy 

分 类 号：R697.3[医药卫生—泌尿科学]