烯烃的氢甲酰化串联反应研究  

Recent Advances on Tandem Hydroformylation of Olefins

作　　者：王鹏[1] 刘欢 杨妲 Peng Wang;Huan Liu;Da Yang(Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;Department of Chemistry,College of Science,China University of Petroleum(East China),Qingdao 266580,China)

机构地区：[1]中国科学院上海有机化学研究所,上海200032 [2]中国石油大学(华东)理学院化学系,青岛266580

出　　处：《化学进展》2022年第5期1076-1087,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21901250)资助。

摘　　要：氢甲酰化串联反应是在氢甲酰化反应的基础上,与一个或多个不同类型的反应“一锅法”实现醛类化合物的后续定向转化,得到新的有机分子的合成方法。该反应的产物在日化工业、农业、医药中间体的生产中具有十分重要的用途。本文首先简述了近年来烯烃氢甲酰化串联反应制备高附加值化学品的重要性,随后重点介绍了几种常见的烯烃氢甲酰化串联反应:“异构化-氢甲酰化”串联反应、“氢甲酰化-缩醛化”串联反应、“氢甲酰化-氢化”串联反应和“氢甲酰化-(还原)胺化”串联反应等,以及其在设计新型(多功能)催化剂体系和高效合成目标产物方面的研究进展,最后总结了烯烃氢甲酰化串联反应存在的问题以及对未来发展趋势进行了展望。Tandem hydroformylation reaction is based on hydroformylation,with one or more different types of reactions"one pot"to achieve the follow-up directional conversion of aldehydes,to get new organic molecules.The products have very important applications in the production of daily chemical industry,agriculture or medical intermediates.In this paper,the importance of olefin tandem hydroformylation to prepare high value-added chemicals in recent years is briefly introduced,then several common tandem hydroformylation(Tandem“Isomerization-hydroformylation”,Tandem“Hydroformylation-acetalization”,Tandem“Hydroformylation-hydrogenation”,Tandem“Hydroformylation-(reductive)amination”)in the design of new(multifunctional)catalyst systems and efficient synthesis of target products are introduced.Finally,the existing problems and future development of the reaction are prospected.

关 键 词：烯烃 氢甲酰化 串联反应 合成气 均相催化 

分 类 号：O643[理学—物理化学] O621.25[理学—化学]