Risk factors of extraneural spreading in astrocytomas and oligodendrogliomas in donors with gliomas: A systematic review  

作　　者：Serena Ammendola Valeria Barresi Elena Bariani Ilaria Girolami Antonia D’Errico Matteo Brunelli Massimo Cardillo Letizia Lombardini Amedeo Carraro Ugo Boggi Owen Cain Desley Neil Albino Eccher 

机构地区：[1]Section of Pathology,Department of Diagnostics and Public Health,University of Verona,Verona 37134,Italy [2]Division of Pathology,Central Hospital,Bolzano 39100,Italy [3]Department of Experimental,Diagnostic and Specialty Medicine(DIMES),University of Bologna,Bologna 40138,Italy [4]National Transplant Center,Istituto Superiore di Sanità,Rome 00161,Italy [5]General Surgery and Liver Transplant Unit,Verona University Hospital,Verona 37126,Italy [6]Division of General and Transplant Surgery,Pisa University Hospital,Pisa 56126,Italy [7]Department of Cellular Pathology,University Hospitals Birmingham NHS Foundation Trust,Birmingham B152GW,United Kingdom [8]Department of Pathology and Diagnostics,Verona University Hospital,Verona 37126,Italy

出　　处：《World Journal of Transplantation》2022年第6期131-141,共11页世界移植杂志

摘　　要：BACKGROUND Patients with a history of primary brain tumors can be eligible for organ donation under extended criteria.The risk assessment of tumor transmission via organ transplant in primary brain tumors is primarily based on the assessment of tumor histotype and grade.Previous surgeries,chemo-/radiotherapy,and ventriculoperitoneal shunt placement can lead to a disruption of the blood-brain barrier,concurring to an increase in the transmission risk.AIM To investigate the role of tumor transmission risk factors in donors with oligodendrogliomas and astrocytomas.METHODS We searched PubMed and EMBASE databases for studies reporting extraneural spreading of oligoden-drogliomas and astrocytomas and extracted clinical-pathological data on the primary tumor histotype and grade,the elapsed time from the diagnosis to the onset of metastases,sites and number of metastases,prior surgeries,prior radiotherapy and/or chemotherapy,ventriculoatrial or ventriculo-peritoneal shunt placement,and the presence of isocitrate dehydrogenase 1/2 mutation and 1p/19q codeletion.Statistical analysis was performed using R software.Statistical correlation between chemotherapy or radiotherapy and the presence of multiple extra-central nervous system metastases was analyzed usingχ2 and Fischer exact test.The Kaplan-Meier method was used to evaluate the presence of a correlation between the metastasis-free time and:(1)Localization of metastases;(2)The occurrence of intracranial recurrences;and(3)The occurrence of multiple metastases.RESULTS Data on a total of 157 patients were retrieved.The time from the initial diagnosis to metastatic spread ranged from 0 to 325 mo in patients with oligodendrogliomas and 0 to 267 mo in those with astrocytomas.Respectively,19%and 39%of patients with oligodendroglioma and astrocytoma did not receive any adjuvant therapy.The most frequent metastatic sites were bone,bone marrow,and lymph nodes.The lungs and the liver were the most commonly involved visceral sites.There was no significant correlation between the o

关 键 词：Metastatic gliomas Extra-central nervous system metastases Tumor transmission Expanded donor Risk factors Transplantation 

分 类 号：R73[医药卫生—肿瘤]