夜间遗尿症儿童静息态脑功能磁共振成像研究  

Resting-state functional magnetic resonance imaging in patients with nocturnal enuresis

作　　者：高婷婷 王梦星 汤伟 董辽 杨光[1] 杜小霞 马骏[4] GAO Tingting;WANG Mengxing;TANG Wei;DONG Liao;YANG Guang;DU Xiaoxia;MA Jun(Department of Physics,Shanghai Key Laboratory of Magnetic Resonance,East China Normal University,Shanghai 200062,China;College of Medical imaging,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;School of Psychology,Shanghai University of Sport,Shanghai 200438,China;Department of Developmental and Behavioral Pediatrics,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]华东师范大学物理与电子科学学院,上海市磁共振重点实验室,上海200062 [2]上海健康医学院医学影像学院,上海201318 [3]上海体育学院心理学院,上海200438 [4]上海交通大学医学院附属上海儿童医学中心发育与行为儿科,上海200127

出　　处：《磁共振成像》2022年第6期71-75,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81901720)。

摘　　要：目的利用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)来探究夜间遗尿症(nocturnal enuresis,NE)儿童的自发脑活动改变机制。材料和方法招募NE患者37例和性别、年龄和教育程度相匹配的健康对照(health control,HC)组37例,所有受试者接受rs-fMRI扫描,通过静息态数据计算NE患者组以及HC组的局部一致性(regional homogeneity,ReHo)和度中心性(degree centrality,DC),使用t检验比较两组之间的差异,提取组间有差异脑区的DC值和ReHo值,与临床指标及《儿童睡眠习惯问卷》(Children’s Sleep Habits Questionnaire,CSHQ)评分进行相关分析。结果与HC组相比,NE患者组在前扣带回、海马旁回的DC值降低,前扣带回ReHo值降低。海马旁回的DC值与异态睡眠的评分呈正相关(P=0.045,r=0.256),与CSHQ总分呈正相关(P=0.010,r=0.062)。结论研究表明NE儿童其静息状态下局部脑功能活动降低,可能与NE的病理有密切关系。Objective:To explore the mechanism of spontaneous brain activity in children with nocturnal enuresis(NE)by resting-state functional magnetic resonance imaging(rs-fMRI).Materials and Methods:NE(n=37)and healthy controls(n=37)matched by gender,age,and education were recruited.All subjects underwent brain rs-fMRI scanning.The resting-state data calculated the regional homogeneity(ReHo)and degree centrality(DC)of children with NE and the healthy control group.A two-sample t-test compared the differences between the two groups.The DC value and ReHo value of brain areas with differences between the two groups were extracted for correlation analysis with clinical indicators and the score of Children’s Sleep Habits Questionnaire(CSHQ).Results:The results of the t-test showed that compared with the healthy control group,the DC value of the NE group decreased in the anterior cingulate gyrus and parahippocampal gyrus of the limbic lobe;Compared with healthy controls,the ReHo value of NE group in the anterior cingulate gyrus decreased.Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of abnormal sleep(P=0.045,r=0.256);Correlation analysis showed that the DC value of the parahippocampal gyrus was positively correlated with the score of CSHQ(P=0.010,r=0.062).Conclusions:The study shows that the decrease of local brain function activity in children with NE at rest may be closely related to the pathology of enuresis.

关 键 词：夜间遗尿症 局部一致性 度中心性 磁共振成像 海马旁回 前扣带回 

分 类 号：R445.2[医药卫生—影像医学与核医学] R694.53[医药卫生—诊断学]