不明原因儿童严重急性肝炎的临床研究进展和挑战  

Clinical progress and challenges of severe acute hepatitis of unknown cause in children

作　　者：李静[1,2] 张敏 福军亮 Zhan Gao 徐哲 LI Jing;ZHANG Min;FU Jun-liang;Zhan Gao;XU Zhe(Senior Department of Infectious Diseases,Peking University 302 Clinical Medical School,100039,China;Senior Department of Infectious Diseases,Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China)

机构地区：[1]北京大学三○二临床医学院感染病医学部,100039 [2]解放军总医院第五医学中心感染病医学部,北京100039 [3]解放军总医院第五医学中心肝病医学部,北京100039 [4]Iowa City,USA,Department of Pathology,the University of Iowa,52242

出　　处：《传染病信息》2022年第3期202-205,共4页Infectious Disease Information

基　　金：国家自然科学基金创新研究群体项目(81721002);国家自然科学基金(82130019)。

摘　　要：2022年4月以来,多个国家或地区相继报告了新发不明原因儿童严重急性肝炎病例,因其可致患儿肝功能恶化等严重后果而引起全球范围内广泛关注。不明原因儿童严重急性肝炎的临床特点、实验室指标检测结果等已有部分报道,但具体致病机制还有待进一步明确。进一步提高应对新突发不明原因疾病的处理能力仍是临床工作者面临的一大挑战。Recently,several countries or regions have been reported new cases of severe acute hepatitis of unknown cause in children,which have attracted worldwide attention due to its serious consequences such as liver failure in children.Clinical features and laboratory tests of these pediatric patients have been reported by several countries,however,further elucidation of the underlying pathogenesis of the diseasein virology,immunology and pathologyis necessary.In addition,improving the ability of pediatricians to manage emerging infectious diseases remains a major challenge.

关 键 词：不明原因儿童严重急性肝炎 急性 重型肝炎 临床特征 致病机制 治疗 进展 挑战 

分 类 号：R725.1[医药卫生—儿科]