人腺病毒感染的病原学研究现状  

Current situation of etiological research on human adenovirus infection

作　　者：朱贞[1] 毛乃颖[1] ZHU Zhen;MAO Nai-ying(NHC Key Laboratory of Medical Viiology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]国家卫生健康委员会医学病毒和病毒病重点实验室中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《传染病信息》2022年第3期206-213,227,共9页Infectious Disease Information

基　　金：“十三五”国家科技重大专项(2018ZX10713002);国家重大公共卫生项目(ZDGW21-131031103000180005)。

摘　　要：人腺病毒(human adenovirus, HAdV)是人类重要的病毒性致病原,可被划分为7个亚属(A~G)和至少113个型别,由于不同型别HAdV的组织嗜性不同,可导致多种疾病,主要包括急性呼吸道感染、眼结膜炎、胃肠道疾病等。2022年1月以来,全球多个国家相继报道了不明原因儿童严重急性肝炎病例,截至5月3日,WHO已接收到20个国家报告的228例病例。目前认为,HAdV感染是引起此次儿童严重急性肝炎的可能病因之一。我国由于缺乏系统的监测和研究而对HAdV感染所致肝炎的疾病负担认识不足,因此应尽快通过医防合作,开展以HAdV为主的非嗜肝病毒的病原学监测,为我国儿童严重急性肝炎的防控提供支持。Human adenovirus(HAdV) is an important viral pathogen in humans and can be divided into 7 species(A ~ G) with at least 113 types. Due to the different tissue tropisms of different types of HAdV, it can lead to a variety of diseases, mainly including acute respiratory infections, conjunctivitis, and gastrointestinal diseases. Since January 2022, cases of acute severe hepatitis of unknown aetiology in children have been reported from many countries around the world. As of May 3, WHO has received 228 cases reported by 20countries. At present, it is considered that HAdV infection is one of the possible causes of acute severe hepatitis in children. Due to the lack of systematic surveillance and research in China, the disease burden of hepatitis caused by HAdV infection is unclear. Therefore,the pathogenic surveillance of non-hepatotropic viruses, mainly HAdV, should be carried out as soon as possible through the cooperation of medical institutions and disease control departments in China, so as to provide support for the prevention and control of acute severe hepatitis in children.

关 键 词：不明原因儿童严重急性肝炎 人腺病毒 病原学 急性呼吸道感染 眼结膜炎 胃肠炎 腺病毒肝炎 实验室监测 

分 类 号：R373[医药卫生—病原生物学]