Effects of alendronate sodium combined with InterTan on osteoporotic femoral intertrochanteric fractures and fracture recurrence  

作　　者：Ke-Meng Wang Shi-Ping Wei Xiao-Yan Yin Qing-Ju Meng Yu-Ming Kong 

机构地区：[1]Department of Orthopedics,First Affiliated Hospital of Xingtai Medical College,Xingtai 054001,Hebei Province,China [2]Department of Basic Medicine,Xingtai Medical College,Xingtai 054001,Hebei Province,China [3]Department of Orthopedics,The First Hospital of Xingtai,Xingtai 054001,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2022年第21期7324-7332,共9页世界临床病例杂志

基　　金：Supported by Special Projects for Social Development Areas.

摘　　要：BACKGROUND Osteoporosis is a global disease affecting 6.6%of the total population.Osteoporosis complications include fractures,increased bone fragility,and reduced bone strength.The most commonly affected parts are the vertebral body,hip,and wrist.AIM To examine the effect of alendronate sodium combined with InterTan for osteoporotic femoral intertrochanteric fractures on bone and fracture recurrence METHODS In total,126 cases of osteoporotic femoral intertrochanteric fractures were selected and divided into two groups according to the 1:1 principle by the simple random method.They were admitted to the Department of Orthopedics,First Affiliated Hospital of Xingtai Medical College,from January 2018 to September 2020.The control group was treated with InterTan fixation combined with placebo,and the observation group with alendronate sodium based on InterTan fixation.Operation-related indicators,complications,and recurrent fractures were compared between the groups.Changes in bone metabolism markers,t value for hip bone mineral density,and Harris Hip Score were observed.RESULTS Operation time,intraoperative blood loss,postoperative ambulation time,and complications were compared between the groups,and no significant difference was found.The fracture healing time was significantly shorter in the observation group than in the control group.β-Collagen-specific sequence(β-CTX)and total aminoterminal propeptide of type I procollagen(T-PINP)in the control group at 3 mo after operation were compared with those before operation,and the difference was not significant.Six months after the operation,theβ-CTX level decreased and T-PINP level increased.β-CTX level at 3 and 6 mo in the observation group after operation was lower,and TPINP level was higher,than that before operation.Compared with the control group,T-PINP level of the observation group was significantly higher andβ-CTX level was significantly lower at 3 and 6 mo after operation.The t value of hip bone mineral density was compared in the control group before an

关 键 词：Alendronate sodium InterTan treatment Osteoporotic femoral intertrochanteric fractures Bone mineral density Hip joint function 

分 类 号：R687.3[医药卫生—骨科学]