Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer  

作　　者：Zhe Wang Guan-Ying Ren Qian Yin Qian Wang 

机构地区：[1]Department of Medical Imaging,The No.2 Hospital of Baoding,Baoding 071051,Hebei Province,China [2]Department of Medical Oncology,Affiliated Hospital of Hebei University,Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy,Baoding 071000,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2022年第21期7333-7340,共8页世界临床病例杂志

基　　金：Supported by Baoding Science and Technology Support Plan Project,No.17ZF211.

摘　　要：BACKGROUND China ranks 120th worldwide for the incidence of breast cancer and 163rd for mortality.Early screening,diagnosis,and timely determination of the optimal treatment plan can help ensure clinical efficacy and prognosis.AIM To investigate the relationship between quantitative magnetic resonance imaging parameters,apparent diffusion coefficient value,pathological immunohistochemical status,and patient prognosis.METHODS A total of 108 patients with breast cancer(breast cancer group)and 110 patients with benign breast tumors(benign group)confirmed by pathological examination at our Hospital from September 2013 to August 2016 were selected.All patients had undergone preoperative magnetic resonance imaging(MRI)examinations,and the quantitative parameters of MRI and apparent diffusion coefficient(ADC)values for the two groups were compared.The MRI quantitative parameters and ADC values of patients with different estrogen receptor(ER),progesterone receptor,and human epidermal growth factor receptor-2 expression were statistically analyzed.The relationship between the quantitative parameters of MRI and ADC values and patient recurrence was analyzed using receiver operating curves.RESULTS The measured values of the quantitative parameters of MRI-Ktrans,Kep,and Ve in the breast cancer group were higher than those in the benign group;the ADC value in the breast cancer group was lower than that in the benign group,and the difference was statistically significant(P<0.05).The Ktrans,Ve,and ADC values in patients with ER-positive breast cancer were significantly lower than those in patients with negative ER expression(P<0.05).After 5 years of follow-up,22 patients with breast cancer experienced postoperative recurrence.The Kep,Ve,and ADC values of the recurrence group were significantly lower than those of the non-recurrence group,and the difference was statistically significant(P<0.05).CONCLUSION MRI quantitative parameters and ADC are related to the expression of breast cancer-related immunological receptor factors and

关 键 词：Magnetic resonance Apparent diffusion coefficient Breast cancer IMMUNOHISTOCHEMISTRY PROGNOSIS 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]