中国哮喘患者吸入给药依从性影响因素的meta分析  

Influencing factors of inhaled medication compliance in Chinese asthma patients:a meta-analysis

作　　者：覃福佳 崔妙玲[1] 农荧[1] 李燕[1] QIN Fujia;CUI Miaoling;NONG Ying;LI Yan(Nursing Department,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 532100,P.R.China)

机构地区：[1]广西医科大学第一附属医院护理部,南宁532100

出　　处：《华西医学》2022年第6期893-901,共9页West China Medical Journal

摘　　要：目的探讨中国哮喘患者吸入给药依从性的影响因素,为提高患者吸入治疗的依从性提供依据。方法检索PubMed、中国知网、万方、维普、中国生物医学文献数据库中建库至2021年12月发表的中国哮喘患者吸入给药依从性影响因素分析的相关文献。采用RevMan 5.2软件进行meta分析。结果共纳入16项研究,研究样本量为2600例,吸入给药依从性好1084例,吸入给药依从性差1516例,吸入给药依从性好的占41.69%。文献质量评价得分均≥4分,均为中等质量及以上。Meta分析显示,影响哮喘患者吸入给药依从性的因素包括患者年龄[比值比(odds ratio,OR)=0.54,95%CI置信区间(confidence interval,CI)(0.32,0.91),P=0.02]、文化程度[OR=0.57,95%CI(0.36,0.90),P=0.02]、医患关系[OR=0.42,95%CI(0.19,0.93),P=0.03]、病情严重程度[OR=0.25,95%CI(0.11,0.58),P=0.001]、哮喘知识掌握程度[OR=2.51,95%(1.11,5.65),P=0.03]、吸入技术掌握程度[OR=8.66,95%CI(3.20,23.40),P<0.0001]以及药物不良反应[OR=0.23,95%CI(0.13,0.41),P<0.00001]。结论中国哮喘患者的吸入给药依从性亟待改善。年龄、文化程度、医患关系、病情严重程度、哮喘知识掌握程度、吸入技术掌握程度、药物不良反应是吸入给药依从性的重要影响因素。Objective To explore the influencing factors of inhalation medication compliance in Chinese asthma patients,and to provide evidence for improving the compliance of patients with inhalation therapy.Methods PubMed,China National Knowledge Infrastructure,Wanfang,Chongqing VIP,and SinoMed were searched for literature on factors influencing inhalation medication compliance in Chinese asthma patients from the establishment of databases to December 2021.Meta-analysis was performed using RevMan 5.2 software.Results A total of 16 studies were included,with a sample size of 2600 cases,1084 cases of good compliance with inhalation administration,1516 cases of poor compliance with inhalation administration,and good compliance with inhalation administration accounted for 41.69%.The literature quality evaluation scores were all≥4 points,all of which were of medium quality and above.Meta-analysis showed that the factors affecting inhalation compliance of asthma patients included age[odds ratio(OR)=0.54,95%confidence interval(CI)(0.32,0.91),P=0.02],educational level[OR=0.57,95%CI(0.36,0.90),P=0.02],doctor-patient relationship[OR=0.42,95%CI(0.19,0.93),P=0.03],disease severity[OR=0.25,95%CI(0.11,0.58),P=0.001],degree of mastery of asthma knowledge[OR=2.51,95%CI(1.11,5.65),P=0.03],degree of mastery of inhalation technique[OR=8.66,95%CI(3.20,23.40),P<0.0001],adverse drug reaction[OR=0.23,95%CI(0.13,0.41),P<0.00001].Conclusion The compliance of inhaled dosing in Chinese asthma patients needs to be improved urgently.Age,education level,doctorpatient relationship,disease severity,mastery of asthma knowledge,mastery of inhalation technology,and adverse drug reactions are the important influencing factors of inhaled medication compliance.

关 键 词：哮喘 吸入给药 依从性 影响因素 META分析 

分 类 号：R562.25[医药卫生—呼吸系统]