肝移植术后人细小病毒感染导致纯红细胞再生障碍性贫血1例  

A case report of pure red blood cell aplastic anemia caused by human parvovirus infection after liver transplantation

作　　者：李国耀 孙纪三[1] 谢炎 孙岩岩 蒋文涛[1] 郭庆军[1] 王洪海[1] Li Guoyao;Sun Jisan;Xie Yan;Sun Yanyan;Jiang Wentao;Guo Qingjun;Wang Honghai(Department of Organ Transplantation,Tianjin First Central Hosipital,Tianjin Clinical Research Center for Organ Transplantation,Tianjin Key Laboratory for Organ Transplantation,Tianjin 300190,China)

机构地区：[1]天津市第一中心医院器官移植中心,天津市器官移植临床医学研究中心,天津市器官移植重点实验室,天津300190

出　　处：《中国医药》2022年第7期1089-1091,共3页China Medicine

基　　金：国家自然科学基金(81870444)。

摘　　要：1例肝移植术后患者出现心悸、气短,血红蛋白进行性下降,经过核酸检测和骨髓活检最终确诊为人细小病毒B19(B19V)感染所致慢性纯红细胞再生障碍性贫血(PRCA)。经过静脉用丙种球蛋白(IVIG)、调整免疫抑制剂和输血等治疗,患者好转。肝移植患者术后出现不明原因贫血,需考虑B19V感染相关PRCA可能,可通过核酸检测和骨髓活检明确诊断,一线治疗方法为IVIG或调整免疫抑制剂及对症治疗。A patient had palpitation,shortness of breath and progressive decrease of hemoglobin after liver transplantation.Based on nucleic acid detection and bone marrow biopsy detection,the patient was finally diagnosed as chronic pure red blood cell aplastic anemia(PRCA)caused by human parvovirus B19(B19 V).After treatment with intravenous immuneglobulin(IVIG),adjustment of immunosuppressant and blood transfusion,the patient′s condition improved.Therefore,patients with anemia of unknown origin after liver transplantation,the possibility of PRCA related to B19 V infection should be considered and the diagnosis could be confirmed by nucleic acid detection and bone marrow biopsy.The first-line treatment was IVIG or adjustment of immunosuppressant and symptomatic treatment.

关 键 词：肝移植 人细小病毒 纯红细胞再生障碍性贫血 

分 类 号：R617[医药卫生—外科学]