血清RBP、CYSC和尿ALB/Cr联合检测对早期糖尿病肾病的诊断价值  

Research on the clinical diagnostic value of joint test of RBP,CYSC,and urinary ALB/Cr in early diabetes nephropathy

作　　者：岳丽 王楠楠 陆群 王正印 Yue Li;Wang Nannan;Lu Qun;Wang Zhengyin(Department of Clinical Laboratory,Taihe County People’s Hospital,Wannan Medical College Affiliated Taihe Hospital,Fuyang 236600,China;Department of Clinical Laboratory,Shanghai TCM Integrated Hospital,Shanghai 200082,China)

机构地区：[1]太和县人民医院皖南医学院附属太和医院检验科,阜阳236600 [2]上海中医药大学附属上海市中西医结合医院检验科,上海200082

出　　处：《中华内分泌外科杂志》2022年第3期283-286,共4页Chinese Journal of Endocrine Surgery

基　　金：国家发改委增强制造业核心竞争力专项基金(2019X000G187);上海市虹口区卫生健康委项目(HKQ-ZYY-2020-33)。

摘　　要：目的探究血清视黄醇结合蛋白(retinol-binding protein,RBP)、胱抑素C(cystatin C,CYSC)和尿白蛋白/肌酐(albumin/creatinine ratio,ALB/Cr)联合检测对早期糖尿病肾病(early diabetic nephropathy,EDN)的临床诊断价值。方法选取2020年1月至2021年06月于太和县人民医院治疗的早期糖尿病肾病患者50例纳入EDN组,单纯2型糖尿病(type 2 diabetes mellitus,T2DM)患者50例纳入T2DM组,健康体检者50例纳入对照组,检测3组受试者血清RBP、CYSC的水平和尿ALB/Cr比值,进一步比较检测单个指标与联合检测该3个指标对EDN的诊断价值。结果EDN组血清RBP、CYSC和尿ALB/Cr分别为(114.66±0.56)mg/L、(2.64±0.33)mg/L、(351.81±15.48)mg/g,均高于T2DM组(83.58±0.83)mg/L、(1.41±0.29)mg/L、(113.65±12.55)mg/g和对照组(38.61±0.66)mg/L、(0.53±0.26)mg/L、(16.36±5.61)mg/g,差异有统计学意义(P<0.05);血清RBP、CYSC和尿ALB/Cr联合检测诊断EDN的特异度与灵敏度分别为95.15%和96.37%,较单个指标检测高。结论血清RBP、CYSC和尿ALB/Cr联合检测对EDN的临床诊断具有一定的参考价值。Objective To investigate the clinical diagnostic value of joint test of retinol-binding protein(RBP),cystatin C(CYSC)and urinary(albumin/creatinine ratio,ALB/Cr)ALB/Cr in early diabetes nephropathy.Methods Data of 50 early diabetic nephropathy patients(EDN group)from Jan.2020 to Jun.2021 in our hospital,another 50 pure type 2 diabetic patients(T2DM group),and 50 healthy subjects(control group)were compared and analysed.RBP,CYSC and urinary ALB/Cr were tested for the 3 groups.Then the clinical diagnostic value between single index test and joint test for the early diabetes nephropathy were compared.Results Group EDN had higher RBP,CYSC and urinary ALB/Cr[(114.66±0.56)mg/L,(2.64±0.33)mg/L,(351.81±15.48)]mg/g than group T2DM[(83.58±0.83)mg/L,(1.41±0.29)mg/L,(113.65±12.55)mg/g]and control group[(38.61±0.66)mg/L,(0.53±0.26)mg/L,(16.36±5.61)mg/g].The difference was statistically significant(P<0.05).The specificity and sensitivity of early diabetes nephropathy were 95.38%and 96.21%,both higher than single index test.Conclusion The combined detection of serum RBP,CYSC and urine ALB/Cr has certain reference value for the clinical diagnosis of early diabetic nephropathy.

关 键 词：黄醇结合蛋白 胱抑素C 尿白蛋白/肌酐 糖尿病肾病 2型糖尿病 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]