溶血磷脂酶PNPLA7的研究进展  

Research Progress in Lysophospholipase PNPLA7

作　　者：王宇[1,2] 常平安 黄飞飞[1,2] WANG Yu;CHANG Ping-an;HUANG Fei-fei(College of Bio-information,Chongqing University of Posts and Telecommunications,Chongqing 400065,China;Chongqing Key Laboratory of Big Data for Bio-intelligence,Chongqing 400065,China)

机构地区：[1]重庆邮电大学生物信息学院,中国重庆400065 [2]重庆市大数据生物智能重点实验室,中国重庆400065

出　　处：《生命科学研究》2022年第3期208-212,共5页Life Science Research

基　　金：国家自然科学基金资助项目(31801139);重庆市自然科学基金项目(cstc2018jcyjAX0120,cstc2020jcyj-mxsmX0007);重庆市留学回国人员创新创业计划项目(RC2020-2)。

摘　　要：含patatin样磷脂酶结构域蛋白7(patatin-like phospholipase domain containing protein 7,PNPLA7)是一种定位于内质网膜上的溶血磷脂酶。PNPLA7在能量代谢和脂质转换活跃的组织中高表达,并且其表达受营养状态的调控。PNPLA7通过与载脂蛋白E相互作用调节极低密度脂蛋白的分泌,进而调控脂肪在肝脏中的积累。环核苷酸,如环腺苷酸,调控PNPLA7与脂肪的储存细胞器脂滴的结合。本文综述了近年PNPLA7的研究现状,并就其未来研究进行了展望。Patatin-like phospholipase domain containing protein 7(PNPLA7)is a lysophospholipase anchored on the endoplasmic reticulum(ER).PNPLA7 is highly expressed in tissues with high levels of energy metabolism and lipid turnover,and its expression is regulated by nutritional status.PNPLA7 regulates the secretion of very-low-density lipoproteins by interacting with apolipoprotein E,controlling the accumulation of triacylglycerol in the liver.In addition,cyclic nucleotides,such as cyclic adenosine monophosphate,regulate the binding of PNPLA7 with lipid droplets,the triacylglycerol storage organelle.Herein,recent progress and prospects of PNPLA7 research are summarized.

关 键 词：PNPLA7蛋白 溶血磷脂酶 脂滴 脂肪代谢 

分 类 号：Q556[生物学—生物化学]