大剂量米非司酮治疗引产后宫腔残留的临床疗效分析  

Clinical Efficacy Analysis of High-dose Mifepristone on Intrauterine Residual after Induced Labor

作　　者：刘朝晖 门晓亮[1] 张河新 沈欢欢 王丹[1] 刘景超 谢文霞[1] 赵丽萍[1] LIU Zhao-hui;MEN Xiao-liang;ZHANG He-xin;SHEN Huan-huan;WANG Dan;LIU Jing-chao;XIE Wen-xia;ZHAO Li-ping(Department of Women’s Health,Daxing Maternal and Child Health Hospital,Beijing 102600,China)

机构地区：[1]北京市大兴区妇幼保健院妇女保健部,北京102600

出　　处：《中国合理用药探索》2022年第6期89-92,共4页Chinese Journal of Rational Drug Use

基　　金：北京市大兴区妇幼保健院院级课题资助项目(2020005)。

摘　　要：目的:探讨大剂量米非司酮治疗乳酸依沙吖啶羊膜腔注射中期妊娠引产后宫腔妊娠组织物残留(RPOC)的临床疗效。方法:选取2020年6月~2022年2月在本院行乳酸依沙吖啶羊膜腔注射中期妊娠引产术、产后经阴道超声示RPOC的73例患者为研究对象,分为对照组(n=27)和观察组(n=46)。对照组给予益母草分散片,观察组给予米非司酮片,两组均连续治疗1周。比较两组治疗有效率、手术率、产后15~17天追加药物率、月经恢复时间、经期时间;观察药物不良反应,如恶心、呕吐、皮疹、阴道大出血、腹痛、感染及肝功能指标。结果:观察组治疗有效率(95.6%)高于对照组(77.8%,P<0.05);观察组手术率(10.9%)低于对照组(25.9%,P<0.05);观察组产后15~17天追加药物率(58.7%)低于对照组(70.4%,P<0.05);观察组有5例出现恶心症状,未出现其他药物不良反应。结论:大剂量米非司酮治疗乳酸依沙吖啶羊膜腔注射中期妊娠引产后RPOC疗效较佳,且安全性较高。Objective:To investigate the clinical efficacy of high-dose mifepristone on the treatment of intrauterine retained products of conception(RPOC)after amniotic cavity injection of acridine lactate for induction of labor during the second trimester.Methods:In our hospital,73 patients with RPOC from June 2020 to February 2022 showed by transvaginal ultrasonography after amniotic cavity injection of acridine lactate for induction of labor during the second trimester were selected,and divided into the control group(n=27)and the observation group(n=46).The control group was given motherwort dispersive tablets,and the observation group was given mifepristone tablets.Both groups were continuously treated for 1 week.The effective rate,operation rate,additional drug rate in 15~17 days after delivery,menstrual recovery time and menstrual period time were compared between the two groups.Adverse drug reactions such as nausea,vomiting,rash,vaginal bleeding,abdominal pain,infection and liver function indexes were observed.Results:The effective rate of the observation group(95.6%)was higher than that of the control group(77.8%,P<0.05).The operation rate in the observation group(10.9%)was lower than that in the control group(25.9%,P<0.05).The rate of additional drugs in 15~17 days after delivery in the observation group(58.7%)was lower than that in the control group(70.4%,P<0.05).There were 5 cases of nausea in the observation group without other adverse drug reactions.Conclusion:High dose mifepristone has better efficacy and safety in the treatment of RPOC induced by amniotic cavity injection of acridine lactate during the second trimester of pregnancy.

关 键 词：大剂量米非司酮 乳酸依沙吖啶 中期引产 宫腔残留 益母草 

分 类 号：R719.3[医药卫生—妇产科学]