新冠病毒核衣壳蛋白及其在病毒感染中的作用  

SARS-CoV-2 nucleocapsid protein: Importance in viral infection

作　　者：H.M.Shifa ul Haq Arnaud JohnKOMBE KOMBE Ayesha Zahid Momal Babar 曾威红 何宏亮 金腾川 H.M.Shifa ul Haq;Arnaud John KOMBE KOMBE;Ayesha Zahid;Momal Babar;Weihong Zeng;Hongliang He;Tengchuan Jin(Department of Obstetrics and Gynecology,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;Laboratory of Structural Immunology,CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Divi-sion of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China;Centre for Applied Molecular Biology(CAMB),University of the Punjab,Lahore 53700,Pakistan;Department of Infectious Diseases,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;CAS Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学技术大学附属第一医院妇产科,中国科学技术大学生命科学与医学部,安徽合肥230001 [2]中国科学技术大学生命科学与医学部基础医学院结构免疫学实验室,中国科学院天然免疫与慢性疾病重点实验室 [3]旁遮普大学应用分子生物学中心,拉合尔53700,巴基斯坦 [4]中国科学技术大学附属第一医院传染病科,中国科学技术大学生命科学与医学部,安徽合肥230001 [5]中国科学院分子细胞科学卓越创新中心,上海200031

出　　处：《中国科学技术大学学报》2022年第6期1-10,I0002,共11页JUSTC

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29030104);the National Natural Science Foundation of China (31870731, 31971129);the Fundamental Research Funds for the Central Universities (WK9100000001);USTC New Medicine Joint Fund Training Program(WK9110000136);China Postdoctoral Science Foundation(2020M670084ZX);Hefei Comprehensive National Science Center (BJ9100000005)。

摘　　要：新型冠状病毒感染引起的新冠肺炎传播已经导致了全世界数百万人的死亡。因此,深入了解新冠病毒的生物学基础对研发控制其传播的新手段至关重要。新冠病毒的核衣壳蛋白(N蛋白)是一个重要的诊断和治疗靶点,它在病毒生命周期中具有多种重要功能。目前已有多个关于新冠病毒N蛋白的结构与功能方面的研究报道。本综述总结了这个进化上高度保守的N蛋白的最新数据,以期提供有关该蛋白的结构和多种功能特征的全面信息。The coronavirus disease 2019(COVID-19) epidemic, caused by severe acute respiratory syndrome coronavirus2(SARS-Co V-2), has caused millions of deaths worldwide. Therefore, it is critical to understand the biological basis of SARS-Co V-2 to develop novel approaches to control its spread. The SARS-Co V-2 nucleocapsid(N) protein is an important diagnostic and potent therapeutic target of the disease, as it is involved in numerous important functions in the viral life cycle. Several studies have explained the structural and functional aspects of the SARS-Co V-2 N protein. This review summarizes the currently available data on the evolutionarily conserved N protein of SARS-Co V-2 by providing detailed information on the structural and multifunctional characteristics of the N protein.

关 键 词：新型冠状病毒 新冠肺炎 核衣壳蛋白 疫苗设计 治疗靶点 

分 类 号：R373.1[医药卫生—病原生物学]