敌草快中毒与Nrf2信号通路关系的研究进展  

Research progress on the relationship between diquat poisoning and nuclear factor E2-related factor 2 signaling pathway

作　　者：王建红 刘同英 周满红 Wang Jianhong;Liu Tongying;Zhou Manhong(Department of Emergency,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou,China)

机构地区：[1]遵义医科大学附属医院急诊科,贵州遵义563003

出　　处：《中华危重病急救医学》2022年第4期444-448,共5页Chinese Critical Care Medicine

基　　金：国家自然科学基金(82060346)。

摘　　要：自2016年我国禁止生产和使用百草枯以来,敌草快(DQ)的使用逐年增加,在临床上DQ中毒的病例也呈现出逐年增加的趋势。DQ中毒的治疗是一个世界性的医学难题,暂无特效解毒剂。据报道,DQ中毒后氧化应激、脂质过氧化、神经毒性作用、生殖与发育毒性在DQ中毒过程中具有关键作用。核因子E2相关因子2(Nrf2)可通过调节其上下游信号分子蛋白表达,抑制氧化应激、脂质过氧化及炎症反应。因此,近年来Nrf2信号通路在DQ中毒及治疗中的作用成为急诊危重症研究人员关注的热点。本文对Nrf2信号通路与DQ中毒的关系进行综述,以期为制定DQ中毒治疗策略提供理论依据。Since the production and use of paraquat was banned in China in 2016,the use of diquat(DQ)has been increasing and the clinical cases of DQ poisoning have also shown an increasing trend every year.The treatment of DQ poisoning is a worldwide medical problem,and there is no specific antidote.Studies have found that oxidative stress,lipid peroxidation,neurotoxicity,reproductive and developmental toxicity play an important role in DQ poisoning.Nuclear factor E2-related factor 2(Nrf2)can inhibit oxidative stress,lipid peroxidation and inflammation by regulating the protein expression of upstream and downstream signaling molecules.Therefore,the role of Nrf2 signaling pathway in the poisoning and treatment of DQ has become a hot spot of attention for emergency critical care researchers in recent years.This paper reviews the relationship between Nrf2 signal pathway and DQ poisoning,in order to provide a theoretical basis for improving the treatment strategy for DQ poisoning.

关 键 词：敌草快 核因子E2相关因子2 氧化应激 脂质过氧化 活性氧 NAD(P)H:醌氧化还原酶1 

分 类 号：R595.4[医药卫生—内科学]