我国人群全身应用糖皮质激素致骨质疏松患病率的Meta分析  

Meta-analysis of the prevalence of osteoporosis induced by systemic glucocorticoid in Chinese population

作　　者：张莉莉[1] 李立东[1] 洪小丽[1] 郭宗晓 ZHANG Li-li;LI Li-dong;HONG Xiao-li;GUO Zong-xiao(Department of Orthopedics,Hai’an People’s Hospital Affiliated to Nantong University,Jiangsu,Nantong,226600,China)

机构地区：[1]南通大学附属海安人民医院骨科,江苏南通226600

出　　处：《现代预防医学》2022年第12期2298-2304,共7页Modern Preventive Medicine

基　　金：江苏省医院协会项目(JSYGY-2-2020-81)。

摘　　要：目的系统分析我国人群全身应用糖皮质激素类药物致骨质疏松的患病率。方法检索CNKI、CBM、万方、维普、Web of Science、PubMed等数据库关于我国人群糖皮质激素相关骨质疏松(glucocorticoid-induced osteoporosis,GIOP)的相关文献,检索时限为建库到2021年9月。应用Stata 15.0软件进行meta分析。结果共纳入24篇文献。Meta分析结果显示:我国人群GIOP总合并患病率为32%(95%CI:26%~39%),糖皮质激素(glucocorticoid,GC)相关骨质减少的总合并患病率为38%(95%CI:31%~44%)。亚组分析显示:肾小球疾病类人群GIOP患病率为13%(95%CI:8%~18%);风湿类疾病人群GIOP患病率为38%(95%CI:30%~46%),其中系统性红斑狼疮和类风湿关节炎的人群的GIOP患病率分别为25%(95%CI:15%~35%)、42%(95%CI:35%~48%);GC用药时间≤12月与用药时间>12月的人群的GIOP患病率依次是27%(95%CI:12%~43%)、34%(95%CI:18%~51%);GC使用剂量≤5mg/d与使用剂量>5mg/d的人群的GIOP患病率依次是45%(95%CI:40%~50%)、54%(95%CI:41%~67%)。结论我国人群全身应用糖皮质激素致骨质疏松的患病率较高,糖皮质激素对骨骼健康的综合影响应引起重视。Objective To systematically analyze the prevalence of osteoporosis caused by systemic application of glucocorticoid in Chinese population.Methods The literatures on glucocorticoid related osteoporosis in Chinese population were searched in CNKI,CBM,Wanfang,VIP,Web of Science and PubMed.The retrieval time limit was from the establishment of the database to September 2021.Meta analysis was performed using stata15.0 software.Results A total of 24literatures were included.The results of meta-analysis showed that the total prevalence of Glucocorticoid-induced Osteoporosis(GIOP)in Chinese population was 32%(95%CI:26%to 39%),and the total prevalence of glucocorticoid related osteopenia was38%(95%CI:31%to 44%).Subgroup analysis showed that the prevalence of GIOP in patients with glomerular diseases was13%(95%CI:8%to 18%)and the prevalence of rheumatic diseases was 38%(95%CI:30%to 46%),the prevalence of systemic lupus erythematosus and rheumatoid arthritis were 25%(95%CI:15%to 35%)and 42%(95%CI:35%to 48%),respectively.The prevalence rates of glucocorticoid use≤12 months and>12 months were 27%(95%CI:12%to 43%)and 34%(95%CI:18%to 51%),respectively.The prevalence of glucocorticoid dose≤5mg/d and>5mg/d were 45%(95%CI:40%to 50%)and 54%(95%CI:41%to 67%),respectively.Conclusion The prevalence of osteoporosis caused by systemic application of glucocorticoid is high in China.The comprehensive effect of glucocorticoid on bone health should be taken seriously.

关 键 词：糖皮质激素性骨质疏松 患病率 中国 META分析 

分 类 号：R58[医药卫生—内分泌]