达比加群酯药物利用评价标准的建立与回顾性分析  

Establishment and retrospective analysis of the evaluation criteria for drug utilization of dabigatran

作　　者：何冬黎 李倩 吕漫 曾露[3] 魏安华[3] HE Dong-li;LI Qian;LYU Man;ZENG Lu;WEI An-hua(Department of Pharmacy,Suizhou Hospital,Hubei University of Medicine,Hubei Suizhou 441300,China;Department of Pharmacy,Wuhan Puren Hospital,Wuhan University of Science and Technology,Hubei Wuhan 430080,China;Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430033,China)

机构地区：[1]湖北医药学院附属随州医院(随州市中心医院)药学部,湖北随州441300 [2]武汉科技大学附属武汉市普仁医院药学部,湖北武汉430080 [3]华中科技大学同济医学院附属同济医院药学部,湖北武汉430033

出　　处：《中国医院药学杂志》2022年第11期1142-1146,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金青年项目(编号:81803841)。

摘　　要：目的:建立达比加群酯药物利用评价标准(drug use evaluation, DUE),为临床合理应用达比加群酯提供参考。方法:以达比加群酯药品说明书为基础,参考相关指南和文献,通过专家咨询法制订达比加群酯药物利用评价标准,并采用回顾性研究方法,对湖北省某大型三甲医院2021年1-6月使用达比加群酯的住院患者用药进行合理性评价,具体包括适应证、用法用量、联合用药、禁忌证、不良反应监测及药物转换等。结果:共纳入501份病例,完全符合评价标准的合理率为91.42%,不合理应用常见于适应证不适宜(2.2%)和用法用量不适宜(2.0%),同时存在30.3%的联合用药的高风险。结论:建立的达比加群酯的DUE具有较强的科学性、实用性和可行性,该院达比加群酯临床应用中尚存在一些问题,应进一步加强干预,促进临床合理用药。OBJECTIVE To establish the drug use evaluation(DUE) criteria for dabigatran, and to provide reference for rational clinical application of dabigatran.METHODS Based on the drug instruction of dabigatran and referring to relevant guidelines and literature, the evaluation criteria for dabigatran utilization were established by expert consultation method. A retrospective study was conducted to evaluate the rationality of dabigatran in inpatients in a large grade A hospital in Hubei province from January to June 2021, including indications, usage and dosage, combination, contraindications, adverse reaction monitoring and drug conversion.RESULTS A total of 501 medical records were included, and the rational rate of fully meeting the evaluation criteria was 91.42%. Unreasonable uses were common in unsuitable indications(2.2%) and unsuitable usage and dosage(2.0%), and there was a high risk for 30.3% combination drug use.CONCLUSION The DUE established for dabigatran is scientific, practical and feasible. There are still some problems in the clinical application of dabigatran in this hospital, and further intervention should be strengthened to promote clinical rational drug use.

关 键 词：达比加群酯 药物利用评价标准 合理用药 专家咨询法 

分 类 号：R963[医药卫生—微生物与生化药学]