Design and evaluation of chitosan-amino acid thermosensitive hydrogel  

作　　者：Jianan Tong Huiyun Zhou Jingjing Zhou Yawei Chen Jing Shi Jieke Zhang Xinyu Liang Tianyuan Du 

机构地区：[1]Chemical Engineering and Pharmaceutics College,Henan University of Science and Technology,Luoyang,471023,China [2]College of Pharmacy(Engineering Research Center for Medicine),Harbin University of Commerce,Harbin,150000,China

出　　处：《Marine Life Science & Technology》2022年第1期74-87,共14页海洋生命科学与技术（英文）

基　　金：support from Natural Science Foundation of Henan Province(No.182300410213);National Natural Science Foundation of China(No.51103035).

摘　　要：Chitosan/glycerophosphate thermosensitive hydrogel crosslinked physically was a potential drug delivery carrier;however, long gelation time limits its application. Here, chitosan-amino acid (AA) thermosensitive hydrogels were prepared from chitosan (CS), αβ-glycerophosphate (GP), and L-lysine (Lys) or L-glutamic acid (Glu). The prepared CS-Lys/GP and CS-Glu/GP hydrogel showed good thermosensitivity and could form gels in a short time. The optimal parameters of CS-Lys/GP hydrogel were that the concentration of CS-Lys was 2.5%, the ratio of CS/Lys was 3.5/1.0, the ratio of CS-Lys/GP was 4.5/1.0. The optimal parameters of CS-Glu/GP hydrogel were that the concentration of CS-Glu was 3.0%, the ratio of CS/Glu was 2.0/1.0, and the ratio of CS-Glu/GP was 4.0/1.5. Chitosan-amino acid (CS-AA) thermosensitive hydrogel had a three-dimensional network structure. The addition of model drug tinidazole (TNZ) had no obvious effect on the structure of hydrogel. The results of infrared spectroscopy showed that there were hydrogen bonds between amino acids and chitosan. In vitro release results showed that CS-Lys/GP and CS-Glu/GP thermosensitive hydrogels had sustained release effects. Thus, the chitosan-amino acid thermosensitive hydrogels hold great potential as a sustained release drug delivery system.

关 键 词：CHITOSAN L-LYSINE L-Glutamic acid αβ-Glycerophosphate Thermosensitive hydrogel In vitro release 

分 类 号：TQ427.26[化学工程]