粪便钙卫蛋白在早期诊断儿童牛奶蛋白过敏相关性腹泻中的应用价值  

Application value of fecal calprotectin in the early diagnosis of milk protein allergy-related diarrhea in children

作　　者：王忠敏 汤卫红 王惠庭 沈林云 杭金国[2] 黄应希[3] WANG Zhongmin;TANG Weihong;WANG Huiting;SHEN Linyun;HANG Jinguo;HUANG Yingxi(The Third Department of Internal Medicine,Hangzhou Children's Hospital,Hangzhou 310000,China;Department of Pediatrics,Taizhou Hospital of Zhejiang Province afficiated to Wenzhou Medical University,Taizhou 318050,China;Department of Pediatrics,the Second Affiliated Hospital of Yichun University,Yichun 336000,China)

机构地区：[1]杭州市儿童医院内三科,浙江杭州310000 [2]浙江省台州医院台州恩泽医疗中心(集团)恩泽医院儿内科,浙江台州318050 [3]江西宜春学院第二附属医院儿科,江西宜春336000

出　　处：《中国现代医生》2022年第16期74-77,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020KY757)。

摘　　要：目的 探讨粪便钙卫蛋白在早期诊断儿童牛奶蛋白过敏相关性腹泻中的应用价值。方法 选取2019年7月~2020年3月于杭州市儿童医院、台州恩泽医疗中心(集团)恩泽医院和江西宜春学院第二附属医院住院的疑似牛奶蛋白过敏相关性腹泻住院患儿60例为疑似组;腹泻组60例取同期因小儿腹泻病住院的儿童;正常组60例取生长发育检查的健康儿童,比较三组的粪便钙卫蛋白水平及疑似组牛奶回避前后粪便钙卫蛋白水平,并与牛奶回避时间进行相关性分析。结果 三组粪便钙卫蛋白水平比较,差异有统计学意义(F=154.33,P<0.01),疑似组显著高于腹泻组(U=12.00,P<0.01);而腹泻组显著高于正常组(U=4.13,P<0.01)。疑似组牛奶回避前和回避后1个月粪便钙卫蛋白水平阳性组显著高于阴性组(U分别为8.99、4.66,P<0.01);牛奶回避后3个月粪便钙卫蛋白水平阳性组与阴性组比较,差异无统计学意义(U=1.47,P>0.05),不同牛奶回避时间粪便钙卫蛋白水平阳性组比较,差异有统计学意义(F=105.16,P<0.01)。结论 粪便钙卫蛋白水平检测对早期识别牛奶蛋白过敏相关性腹泻有一定的参考价值。Objective To investigate the application value of fecal calprotectin in the early diagnosis of milk protein allergy-related diarrhea in children. Methods Sixty hospitalized children with suspected milk protein allergy-related diarrhea from July 2019 to March 2020 were selected as the suspected group. Sixty children with diarrhea due to pediatric diarrhea in the same period were selected as the hospitalized children. Sixty healthy children with growth and development examination were selected as the normal group. The fecal calprotectin levels in the three groups and the fecal calprotectin levels before and after milk avoidance in the suspected group were compared. The correlation between fecal calprotectin levels and milk avoidance time was analyzed. Results There were significant differences in fecal calprotectin levels among the three groups(F=154.33, P<0.01).The fecal calprotectin in the suspected group was significantly higher than in the diarrhea group(U=12.00, P<0.01).While the fecal calprotectin in the diarrhea group was significantly higher in the diarrhea group than in the normal group(U=4.13,P<0.01). The fecal calprotectin level in the positive group was significantly higher than in the negative group before milk avoidance and one month after avoidance(U were 8.99, 4.66,P<0.01).There was no significant difference in the fecal calprotectin level between the positive group and the negative group 3 months after milk avoidance(U=1.47, P>0.05).There was a significant difference in the fecal calprotectin level in the positive group at different milk avoidance times(F=105.16, P<0.01). Conclusion The detection of fecal calprotectin level has a certain reference value for early identification of milk protein allergy-related diarrhea.

关 键 词：牛奶蛋白过敏相关性腹泻 粪便钙卫蛋白 牛奶回避 早期识别 

分 类 号：R725.7[医药卫生—儿科]