耐甲氧西林表皮葡萄球菌血流感染预后因素分析  

Analysis of related factors of blood flow infection in methicillin resistant saphylococcus epidermidis

作　　者：李薇 吴海波 王丹 林娜 王雪莹 许昌海 栾亮 Li wei;Wu Haibo;Wang Dan;Lin Na;Wang Xueying;Xu Changhai;Luan Liang(Department of Intensive Care Unit,General Hospital of Northern Theater Command,Shenyang 110016,China;Department of Clinical Laboratory,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]北部战区总医院重症医学科,沈阳110016 [2]北部战区总医院检验科,沈阳110016

出　　处：《中国临床实用医学》2022年第2期61-64,共4页China Clinical Practical Medicine

基　　金：辽宁省科学技术计划项目(2021-MS-046)。

摘　　要：目的根据耐甲氧西林表皮葡萄球菌(MRSE)感染患者的预后转归情况, 分析影响预后的危险因素。方法本研究为回顾性研究, 收集2020年1月至2020年12月在北部战区总医院沈河院区所有临床科室住院治疗的42例MRSE血流感染患者的临床资料(数据选取自检验科), 男33例, 女9例, 年龄(53±19)岁, 年龄范围为16~96岁。根据经有效抗生素治疗后的情况, 将经有效抗生素治疗后正常出院的患者为预后好转组, 经积极抗感染治疗后病死或放弃治疗要求出院的患者为非好转组。将全部待研究因素纳入单因素分析, 单因素分析有显著统计学意义的结果纳入多因素分析。结果预后好转组与非好转组性别、年龄、使用抗生素时长、手术、机械通气、免疫抑制、颅脑疾病或损伤、肺部基础疾病、肾功能不全比较, 差异无统计学意义(P>0.05);住院时长、抗生素应用种类、入住ICU、留置尿管、患有心脏疾病及高血糖比较, 差异有统计学意义(P<0.05)。单因素logistic回归分析结果表明住院时长、抗生素种类、心脏疾病以及高血糖与不同预后情况间存在显著关联, 提示其可能是导致患者MRSE血流感染预后不佳的危险因素。将其进行多因素logistic回归分析, 结果表明有心脏疾病及高血糖与患者MRSE血流感染预后间存在显著关联, 提示可能是导致MRSE血流感染预后不佳的独立危险因素。结论心脏疾病史以及高血糖可能是影响MRSE患者预后的危险因素。Objective Risk factors affecting the prognosis were analyzed according to the outcome of patients with methicillin resistant saphylococcus epidermidis(MRSE)infection.Methods This study was a retrospective study,collecting clinical data of 42 patients hospitalized in all clinical departments from January 2020 to Shenhe General Hospital in December 2020(data selected from Laboratory),33 males and 9 females,age(53±19)years old,age range from 16 to 96 years old.According to the situation after effective antibiotic treatment,patients who were normally discharged after effective antibiotic treatment were in the improved prognosis group,and those who died after active anti-infection treatment were in the non-improved group.All factors to be studied were included in the univariate analysis,and results with significant univariate analysis were included in the multivariate analysis.Results Better prognosis and non-improvement group in sex,age,antibiotic duration,surgery,mechanical ventilation,immunosuppression,brain disease,or injury,lung disease,renal insufficiency,the differences were no statistically significant(P>0.05),in hospital length,antibiotic application,ICU,catheterization,heart disease,and hyperglycemia,the differences were statistically significant(P<0.05).The results of univariate logistic regression analysis indicated a significant association between length of hospitalization,antibiotic type,cardiac disease,and hyperglycemia and different prognosis conditions,suggesting that it may be a risk factor for poor prognosis of MRSE.Multivariate logistic regression analysis showed a significant association between cardiac disease and MRSE,suggesting that it may be an independent risk factor for poor prognosis of MRSE.Conclusions A history of cardiac disease as well as hyperglycemia may be risk factors affecting the prognosis of patients with MRSE.

关 键 词：耐甲氧西林表皮葡萄球菌 危险因素 心脏疾病 

分 类 号：R446.5[医药卫生—诊断学]