TURBT联合吉西他滨对膀胱癌患者SVEGFR1、IGFBP-3、IMP3表达的影响  

Effects of TURBT combined with gemcitabine on expression of SVEGFR1, IGFBP-3 and IMP3 in patients with bladder cancer

作　　者：蔡仙国[1] 卢子文[1] 李卫林 吴宏剑 CAI Xianguo;LU Ziwen;LI Weilin;WU Hongjian(Departmentof Urology Surgery,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou 317000,China)

机构地区：[1]浙江省台州医院泌尿外科,浙江台州317000

出　　处：《中国现代医生》2022年第17期15-18,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020KY1038)。

摘　　要：目的 探讨尿道等离子电切术(TURBT)联合吉西他滨对膀胱癌患者的可溶性血管内皮生长因子受体1(SVEGFR1)、血清胰岛素样生长因子结合蛋白-3(IGFBP-3)、胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)表达的影响。方法 收集2015年1月~2018年4月浙江省台州医院泌尿外科治疗的101例膀胱癌患者资料并进行回顾性分析,随机分为对照组与研究组,对比两组的临床疗效。采用酶联免疫吸附法检测SVEGFR1水平、全自动化学发光分析仪测定IGFBP-3水平、免疫组化法测定IMP3水平。结果 治疗后,血清DKK1、CYFRA21-1、VEGF水平降低,IGFBP-3水平升高,相比对照组,研究组SVEGFR1、IMP3、DKK1、CYFRA21-1、VEGF水平较低,IGFBP-3水平较高(P<0.05);对照组术后1年、3年复发率及复发时间均较高于研究组,研究组不良反应总发生率高于对照组(P>0.05)。结论 TURBT联合吉西他滨治疗可提高膀胱癌患者的治疗效果,可延长膀胱癌患者的生存时间,且毒副作用小,安全性较好,值得临床推广。Objective To investigate the effect of Human soluble vascular endotherial growth factor receptor1(SVEGFR1)urethral plasmakinetic resection(TURBT)and gemcitabine on the expression of insulin-like growth factor binding protein-3(IGFBP-3)and insulin-like growth factor II mRNA binding protein 3(IMP3)in patients with bladder cancer.Methods A total of 101 patients with bladder cancer treated were collected in Departmentof Urology Surgery,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University from January 2015 to April 2018 and analyzed retrospectively.They were randomly divided into the control group and the research group,and the clinical efficacy of the two groups was compared.The levels of svegfr1,IGFBP-3 and IMP3 were measured by enzyme-linked immunosorbent assay,automatic chemiluminescence analyzer and immunohistochemistry.Results After treatment,the levels of serum DKK1,CYFRA21-1 and VEGF decreased and the levels of IGFBP-3 increased.Compared with the control group,the levels of SVEGFR1,IMP3,DKK1,CYFRA21-1 and VEGF in the study group were lower and the levels of IGFBP-3 were higher(P<0.05);The recurrence rate at 1 and 3 years after operation in the control group was higher than that in the study group,and the total incidence of adverse reactions and tine to relapse in the study group was higher than that in the control group(P>0.05).Conclusion TURBT combined with gemcitabine can improve the therapeutic effect of bladder cancer,prolong the survival time of patients with bladder cancer,and have less toxic side effects and better safety,which is worthy of clinical promotion.

关 键 词：尿道等离子电切术 吉西他滨 膀胱癌 影响 

分 类 号：R699.2[医药卫生—泌尿科学]