CCR6、p38在鼻咽癌组织中的表达及临床意义  

Expression and clinical significance of CCR6 and p38 in nasopharyngeal carcinoma

作　　者：王素珍 张洁民 WANG Suzhen;ZHANG Jiemin(Department of Otolaryngology Head and Neck Surgery,Wuwei People’s Hospital,Gansu,Wuwei 733000,China;不详)

机构地区：[1]甘肃省武威市人民医院耳鼻喉头颈外科,733000 [2]甘肃省武威市人民医院病理科,733000

出　　处：《河北医药》2022年第13期1948-1951,1956,共5页Hebei Medical Journal

基　　金：武威市科技计划项目(编号:WW1902010)。

摘　　要：目的 研究CC趋化因子受体6(CCR6)、p38在鼻咽癌(NPC)组织中的表达水平,并分析二者与NPC患者临床病理特征及预后的关系。方法 选取2015年3月至2017年9月诊治的91例NPC患者为研究对象,收集NPC组织、癌旁正常组织,免疫组化法测定CCR6、p38蛋白表达水平;分析NPC组织CCR6、p38蛋白表达水平与患者临床病理特征的关系;Spearman等级相关性分析NPC组织中CCR6表达水平与p38的相关性;Kaplan-Meier生存曲线分析NPC组织CCR6、p38表达水平与患者预后的关系;COX回归分析NPC患者预后的影响因素。结果 NPC组织CCR6、p38蛋白阳性表达率均显著高于癌旁正常组织(P<0.05);NPC组织CCR6、p38表达水平均与肿瘤淋巴结转移、TNM分期、分化程度明显相关(P<0.05),与性别、吸烟史、年龄无相关性(P>0.05);NPC组织中CCR6表达水平与p38呈正相关(r=0.583,P<0.05);Kaplan-Meier生存曲线分析显示,CCR6、p38阳性组NPC患者术后36个月累积生存率明显低于CCR6、p38阴性组(P<0.05);淋巴结转移、p38、TNM分期、CCR6是影响NPC患者预后的独立危险因素(P<0.05)。结论 NPC患者癌组织CCR6、p38阳性表达率较高,两者均与NPC临床病理特征及预后相关,CCR6、p38有望成为评估NPC患者预后的指标。Objective To investigate the expression levels of CC chemokine receptor 6(CCR6)and p38 in nasopharyngeal carcinoma(NPC),and analyze their correlation with clinicopathological features and prognosis of patients with NPC.Methods A total of 91 patients with NPC who were treated in our hospital from March 2015 to September 2017 were enrolled as research objects.The NPC tissues and adjacent normal tissues were collected,immunohistochemistry was used to detect the expression levels of CCR6 and p38 protein,and Chi square test was used to analyze the correlation between the expression levels of CCR6 and p38 protein in NPC tissues and the clinicopathological features of patients with NPC.Spearman rank correlation analysis was used to analyze the correlation between the expression levels of CCR6 and p38 in NPC tissues;Kaplan-Meier survival curve was used to analyze the correlation between the expression levels of CCR6,p38 and the prognosis of patients;COX regression analysis was used to analyze the prognostic factors of patients.Results The positive expression rates of CCR6 and p38 in NPC tissues were significantly higher than those in adjacent normal tissues(P<0.05),moreover,which in NPC tissues were significantly correlated with lymph node metastasis,TNM stage and degree of differentiation(P<0.05),however,which were not correlated with patient’s gender and age,and smoking history(P>0.05).The expression levels of CCR6 were positively correlated with those of p38 in NPC(P<0.05).Kaplan-Meier survival curve analysis showed that the 36-month cumulative survival rate of patients in CCR6 and p38 positive groups was significantly lower than that in CCR6 and p38 negative groups(P<0.05).In addition lymph node metastasis,p38,TNM stage and CCR6 were independent risk factors for the prognosis of patients with NPC(P<0.05).Conclusion The positive expression rates of CCR6 and p38 in NPC tissues are higher,both of them are related to the clinicopathological characteristics and prognosis of patients with NPC,and CCR6 and p38 may be rega

关 键 词：CC趋化因子受体6 P38 鼻咽癌 预后 

分 类 号：R766.3[医药卫生—耳鼻咽喉科]