miR-29家族与骨性关节炎的相关研究进展  

Related research progress of miR-29 family and osteoarthritis

作　　者：张维 崔国峰 武军龙[2] 岳辰 刘丹 张静 刘瑞宇 魏戎[2] ZHANG WEI;CUI Guofeng;WU Junlong;YUE Chen;LIU Dan;ZHANG Jing;LIU Ruiyu;WEI Rong(Xinxiang Medical University,Xinxiang 453003;Orthopaedics Department,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000;Orthopaedics Department,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004;Orthopaedics Department,Luoyang Orthopedic-Traumatological Hospital of Henan Province,Luoyang 471002;Rheumatic Immunology Department,Xi'an No.5 Hospital,Xi'an 710082,China)

机构地区：[1]新乡医学院,河南新乡453003 [2]郑州大学附属洛阳中心医院骨科,河南洛阳471000 [3]西安交通大学第二附属医院骨科,陕西西安710004 [4]河南省洛阳正骨医院骨科,河南洛阳471002 [5]西安市第五医院风湿免疫科,陕西西安710082

出　　处：《临床医学研究与实践》2022年第20期196-198,共3页Clinical Research and Practice

基　　金：2021年第一批洛阳市应用技术研究与开发项目(No.2101027A);2019年度河南省医学科技攻关计划联合共建项目(No.LHGJ20191226);2020年西安市第七批科技计划项目[No.20YXYJ0003(7)]。

摘　　要：微小RNAs(miRNAs)是一种小非编码RNAs,可以结合信使RNA(mRNA)的3'-非翻译区(3'-UTR)靶点,进而调节转录后基因的表达。越来越多的证据表明,miR-29家族(包括miR-29a、miR-29b-1、miR-29b-2和miR-29c)是多种生物过程中的关键调控因子;此外,miR-29家族的异常表达也是许多疾病的病因之一。本文旨在总结miR-29家族在骨性关节炎(OA)中的差异性表达方式和功能作用,同时探讨miR-29家族在此类疾病中潜在的靶向治疗作用。miR-29家族可通过抑制靶基因促进成骨细胞的分化和凋亡,同时可抑制软骨分化、破骨细胞分化。进一步研究miR-29家族在此类疾病中的作用机制及其在治疗方面的潜在作用至关重要。MicroRNAs(miRNAs)are small noncoding RNAs that bind to targets in the 3'-untranslated region(3'-UTR)of messenger RNA(mRNA),thereby regulating post-transcriptional gene expression.More and more evidences show that miR-29 family(including miR-29a,miR-29b-1,miR-29b-2 and miR-29c)is a key regulator in a variety of biological processes;in addition,the abnormal expression of miR-29 family is also one of the causes of many diseases.This article aims to summarize the differential expression and functional roles of miR-29 family in osteoarthritis(OA),and to explore the potential targeted therapeutic effects of the miR-29 family in this disease.The miR-29 family can promote the differentiation and apoptosis of osteoblasts by inhibiting target genes,and inhibit the differentiation of chondrocytes and osteoclasts at the same time.Further studying the action mechanism of the miR-29 family in such diseases and their potential role in therapy are critical.

关 键 词：微小RNA MIR-29 骨性关节炎 

分 类 号：R684.3[医药卫生—骨科学]