有氧运动对2型糖尿病患者认知功能影响的Meta分析  

Meta-analysis of the effect of aerobic exercise on cognitive function in patients with type 2 diabetes

作　　者：王雪[1] 陈海根 罗婷 郭宏[1] Wang Xue;Chen Haigen;Luo Ting;Guo Hong

机构地区：[1]沈阳医学院,110034

出　　处：《中国疗养医学》2022年第8期813-817,共5页Chinese Journal of Convalescent Medicine

基　　金：辽宁省社会科学规划基金项目(L21BRK005);沈阳医学院研究生科技创新基金项目(Y20210514)。

摘　　要：目的系统评价有氧运动干预对2型糖尿病患者认知功能的作用。方法在维普科技期刊全文数据库、万方数据库、中国科技知网数据库、Pubmed、Embase、The Cochrane Library中系统检索文献(建库至2021年12月),检索有氧运动对2型糖尿病患者认知功能的随机对照研究。由2位评价员独立筛查文献、提取数据后,使用Cochrane进行偏倚风险的评估,选取录入有效的信息,使用RevMan 5.3统计软件进行数据分析。结果最终纳入10项研究,涉及961名研究对象。Meta分析结果显示,与无运动相比,实施有氧运动干预的试验组伴轻度认知功能障碍(MCI)的2型糖尿病患者认知功能得分提高[SMD=0.75,95%CI(0.60,0.91),P<0.0001];试验组研究对象的简易精神状况量表(MMSE)评分[MD=1.86,95%CI(0.77,2.95),P<0.05]、蒙特利尔认知评估量表(MoCA)评分[MD=1.67,95%CI(0.87,2.47),P<0.0001]提高;试验组进行有氧运动干预3个月后认知水平得分[SMD=0.70,95%CI(0.38,1.02),P<0.0001]、6个月后[SMD=0.70,95%CI(0.02,1.39),P<0.05]、12个月后[SMD=0.74,95%CI(0.49,1.00),P<0.0001]均比对照组提高。结论有氧运动可以有效改善2型糖尿病患者的认知水平,且干预时间越长效果越好,但还需要更多更高质量的研究进一步证实研究结果。Objective To systematically evaluate the effect of aerobic exercise intervention on cognitive function in patients with type 2 diabetes.Methods A randomized controlled study on the effect of aerobic exercise on cognitive function of patients with type 2 diabetes was retrieved from the full-text database of VIP scientific journals,Wanfang database,CNKI database,Pubmed,Embase,and the Cochrane Library(from the database establishment to December 2021).After two evaluators independently screened the literature and extracted the data,Cochrane was used to assess the bias risk,effective information was selected and entered,and Revman 5.3 statistical software was used for data analysis.Results Finally,10 studies involving 961 subjects were included.The results of Meta-analysis showed that compared with no exercise,the cognitive function score of type 2 diabetes patients with mild cognitive impairment(MCI)in the experimental group with aerobic exercise intervention was improved[SMD=0.75,95%CI(0.60,0.91),P<0.0001];The MMSE scores[MD=1.86,95%CI(0.77,2.95),P<0.05]and the MoCA scores[MD=1.67,95%CI(0.87,2.47),P<0.0001]of the subjects in the experimental group were improved;The cognitive level scores of the experimental group after 3 months'aerobic exercise intervention were[SMD=0.70,95%CI(0.38,1.02),P<0.0001],after 6 months[SMD=0.70,95%CI(0.02,1.39),P<0.05],after 12 months[SMD=0.74,95%CI(0.49,1.00),P<0.0001]were higher than those of the control group.Conclusion Aerobic exercise can effectively improve the cognitive level of patients with type 2 diabetes,and the longer the intervention time,the better the effects.However,more and higher quality studies are needed to further confirm the research results.

关 键 词：有氧运动 2型糖尿病 认知功能 系统评价 

分 类 号：R587.1[医药卫生—内分泌]