乳酸杆菌联合甲硝唑治疗妊娠合并滴虫性阴道炎的临床疗效  

Clinical Efficacy of Lactobacillus Combined with Metronidazole in the Treatment of Pregnancy Complicated with Trichomonal Vaginitis

作　　者：黄小娟[1] HUANG Xiaojuan(Fujian Zhangzhou Hospital of Traditional Chinese Medicine,Zhangzhou 363000,China)

机构地区：[1]福建省漳州市中医院,福建漳州363000

出　　处：《中国医药指南》2022年第19期43-46,共4页Guide of China Medicine

摘　　要：目的对妊娠合并滴虫性阴道炎患者应用乳酸杆菌+甲硝唑治疗的临床疗效进行探讨和分析。方法将98例妊娠合并滴虫性阴道炎患者按照随机数字表法分成观察组与对照组各49例,对照组患者采取单一甲硝唑治疗7 d,观察组则应用甲硝唑联合乳酸杆菌治疗7 d,对两组患者治疗效果、阴道分泌物炎性因子指标变化、阴道滴虫转阴率、复发率、乳酸杆菌阳性及产H2O2阳性率以及不良反应发生率进行对比。结果观察组患者治疗总有效率为95.92%,显著高于对照组的81.63%(P<0.05)。治疗前,两组在阴道分泌物炎性因子水平上比较,差异无统计学意义(P>0.05);治疗后,观察组患者的IL-2、IL-8、IL-13指标的改善程度明显优于对照组(P<0.05)。经7 d对症治疗后,对比阴道滴虫转阴率及复发率均无明显组间差异(P>0.05),而经治疗3个月后,观察组阴道转阴率较对照组明显更高(91.84%vs.75.51%),观察组复发率较对照组明显更低(6.12%vs.22.45%),差异有统计学意义(P<0.05)。治疗后观察组菌落面积≥1/2阴道面积占比、产H2O2阳性数占比分别为77.55%、46.94%,均显著高于对照组的53.06%、20.41%,差异有统计学意义(P<0.05)。对比治疗期间两组不良反应发生情况,组间无明显差异(4.08%vs.6.15%)(P>0.05)。结论应用乳酸杆菌联合甲硝唑治疗妊娠合并滴虫性阴道炎效果满意,可有效缓解阴道炎性反应,促进阴道滴虫转阴及降低复发,且不良反应发生率低。Objective To discuss and analyze the clinical efficacy of lactobacillus+metronidazole in the treatment of pregnancy complicated with trichomonas vaginitis.Methods Ninety-eight cases of pregnancy complicated with trichomonal vaginitis were randomly divided into observation group and control group,with 49 cases in each group.The patients in the control group were treated with single metronidazole for 7 days,while the patients in the observation group were treated with metronidazole combined with lactobacillus for 7 days.The treatment effect,the changes of inflammatory factors in vaginal secretions,the negative rate of trichomonas vaginalis,the recurrence rate,the positive rate of lactobacillus and H2O2 positive rate,and the incidence of adverse reactions were compared.Results The total effective rate of treatment in the observation group was 95.92%,which was significantly higher than 81.63%in the control group(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors in vaginal secretions between the two groups(P>0.05).After treatment,the improvement of IL-2,IL-8 and IL-13 indexes in the observation group was significantly better than that in the control group(P<0.05).After 7 days of symptomatic treatment,there was no significant difference between the groups in the negative rate and recurrence rate of Trichomonas vaginalis(P>0.05),while the negative conversion rate after 3 months of treatment was significantly higher in the observation group(91.84%vs.75.51%),and the recurrence rate in the observation group was significantly lower(6.12%vs.22.45%),the difference in indicators was statistically significant(P<0.05).After treatment,the proportion of colony area≥1/2 of vaginal area and the proportion of positive H2O2 production in the observation group were 77.55%and 46.94%,which were significantly higher than those in the control group(53.06%,20.41%),the difference was statistically significant(P<0.05).During the treatment period,there was no significant difference in the occu

关 键 词：乳酸杆菌 甲硝唑 妊娠 滴虫性阴道炎 炎性因子 临床疗效 

分 类 号：R711.31[医药卫生—妇产科学]