老年肺结核患者服用抗肺结核药物治疗的有效性及对痰菌转阴率的影响分析  

Analysis of the efficacy of anti-tuberculosis drug therapy in elderly patients with pulmonary tuberculosis and effects on the sputum negative conversion rate

作　　者：黄秋琴 HUANG Qiuqin(Department of Pulmonology,Hopsital,Changsha Central Hospital,Changsha 410004,China)

机构地区：[1]长沙市中心医院肺科医院三病室,湖南长沙410004

出　　处：《中国现代医生》2022年第18期137-140,共4页China Modern Doctor

摘　　要：目的探讨老年肺结核患者采用抗肺结核药物治疗的价值。方法筛选长沙市中心医院肺科医院三病室2019年1月~2021年1月收治的80例老年肺结核患者,并按随机数字表法分为两组,每组各40例,对照组采用抗肺结核药物治疗,观察组在对照组基础上采用薄芝糖肽治疗,对比两组的临床疗效、不良反应率、痰菌转阴率、临床指标。结果观察组临床总有效率(92.50%)高于对照组(75.00%)(χ^(2)=4.501,P<0.05);观察组不良反应发生率(22.50%)与对照组(20.00%)比较,差异无统计学意义(χ^(2)=0.088,P>0.05);观察组治疗后1个月(45.00%)、6个月(60.00%)、12个月(95.00%)痰菌转阴率高于对照组(P<0.05);观察组CRP、PCT低于对照组,痰菌转阴时间短于对照组,FEV1、FEV1/FVC高于对照组(P<0.05)。结论在抗肺结核药物治疗基础上选择薄芝糖肽注射液对老年肺结核进行治疗可确保治疗安全性及有效性,值得参考。Objective To explore the value of anti-tuberculosis drug therapy in elderly patients with pulmonary tuberculosis.Methods A total of 80 elderly patients with pulmonary tuberculosis who were admitted to the Ward III of Pulmonology Department of Changsha Central Hospital from January 2019 to January 2021 were selected as study subjects and divided into two groups according to the random method,with 40 cases in each group.The control group received anti-tuberculosis drugs,while the observation group received Bozhi glycopeptide on the basis of treatment of the control group.The clinical efficacy,adverse reaction rate,sputum negative conversion rate and clinical indicators were compared between the two groups.Results The total efficacy rate of the observation group(92.50%)was higher than that of the control group(75.00%)(χ^(2)=4.501,P<0.05);there was no difference in the adverse reaction rate between the observation group(22.50%)and the control group(20.00%)(χ^(2)=0.088,P>0.05);the sputum negative conversion rate at 1 months(45.00%),6 months(60.00%)and 12 months(95.00%)after treatment in the observation group was higher than that in the control group(P<0.05);for the observation group,the CRP and PCT after treatment were lower than those in the control group,the sputum negative conversion time was shorter than that in the control group,and FEV1 and FEV1/FVC were higher than those in the control group(P<0.05).Conclusion On the basis of anti-tuberculosis drug therapy,Bozhi glycopeptide injection can ensure the safety and efficacy of the treatment of elderly pulmonary tuberculosis,which is worthy of reference.

关 键 词：老年 肺结核 抗肺结核药物 痰菌转阴率 白介素-6 

分 类 号：R521.6[医药卫生—内科学]