丙泊酚、七氟醚联合艾司氯胺酮应用于小儿腹部短小手术中的麻醉效果及不良反应发生情况  

Anesthetic Effect and Adverse Reactions of Propofol,Sevoflurane Combined with Esketamine in Pediatric Short Abdominal Surgery

作　　者：张小虹 牛艳姣 杨中贞 贾雅蕊[1] 苗韶华[1] ZHANG Xiao-Hong;NIU Yan-Jiao;YANG Zhong-Zhen;JIA Ya-Rui;MIAO Shao-Hua(Department of Anesthesiology,Heze municipal hospital,Heze 274031,China)

机构地区：[1]菏泽市立医院麻醉科,山东菏泽274031

出　　处：《中国药物经济学》2022年第5期99-102,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨丙泊酚、七氟醚联合艾司氯胺酮应用于小儿腹部短小手术中的麻醉效果及不良反应发生情况。方法选取2020年6月至2021年5月在菏泽市立医院外科住院行腹部短小手术的160例患儿作为研究对象,根据随机、双盲原则分为观察组和对照组,每组80例。在麻醉诱导期,观察组给予艾司氯胺酮0.5 mg/kg+丙泊酚2 mg/kg静脉滴注,对照组给予舒芬太尼0.1μg/kg+丙泊酚2 mg/kg静脉滴注,术中两组应用4%七氟醚持续吸入维持麻醉状态。记录两组患儿年龄、体重、美国麻醉医师协会(ASA)分级、手术时间等一般情况;观察两组麻醉开始前(T1)、麻醉诱导后(T2)、麻醉持续5 min(T3)及15 min(T4)、手术结束时(T5)、术后苏醒时(T6)的平均动脉压、血氧饱和度;记录两组患儿麻醉诱导时间、苏醒时间、麻醉不良反应并分析。结果两组患儿年龄、体重、ASA分级、手术时间及失血量比较,差异无统计学意义(P>0.05)。两组患儿各时间节点平均动脉压、血氧饱和度比较差异无统计学意义(P>0.05),但观察组患儿平均动脉压、血氧饱和度波动范围小于对照组(P<0.05)。观察组患儿麻醉诱导时间、苏醒时间短于对照组(P<0.05)。观察组在麻醉诱导期、术后苏醒期不良反应少于对照组(P<0.05)。结论在小儿腹部短小手术中,丙泊酚、七氟醚复合艾司氯胺酮麻醉时患儿血流动力学更平稳,麻醉效果更好且不良反应更少。Objective To observe the anesthetic effect and adverse reactions of Propofol,Sevoflurane combined with Esketamine in pediatric short abdominal surgery.Methods From June 2020 to May 2021,160 children with abdominal short operation in Heze municipal hospital were selected as the research objects.According to the principle of random and double-blind,the children were divided into observation group and control group,80 in each group.During the anesthesia induction period,the observation group was given intravenous injection of 0.5 mg/kg of ketamine and 2 mg/kg of propofol,while the control group was given intravenous injection of 0.1μg/kg of sufentanil and 2 mg/kg of propofol.Both groups were given continuous inhalation of 4%sevoflurane to maintain anesthesia.The age,weight,ASA grade and operation time of the two groups were recorded;The mean arterial pressure and blood oxygen saturation were observed before anesthesia(T1),after anesthesia induction(T2),anesthesia lasting for 5 minutes(T3)and 15 minutes(T4),at the end of operation(T5)and after recovery(T6)were observed;Anesthesia induction time,recovery time and adverse reactions were recorded and analyzed.Results There were no significant difference in age,weight,ASA grade,operation time and blood loss between the two groups(P>0.05).There were no significant difference in mean arterial pressure and blood oxygen saturation between the two groups at each time point(P>0.05),but the fluctuation range of mean arterial pressure and blood oxygen saturation in the observation group was smaller than that in the control group(P<0.05).The induction time and recovery time of anesthesia in the observation group were significantly less than those in the control group(P<0.05).The adverse reactions in the observation group during anesthesia induction and postoperative recovery were significantly less than those in the control group(P<0.05).Conclusions In pediatric short abdominal surgery,when propofol,sevoflurane combined with esmketamine anesthesia,the hemodynamics of children is

关 键 词：艾司氯胺酮 丙泊酚 七氟醚 舒芬太尼 腹部短小手术 

分 类 号：R614[医药卫生—麻醉学] R971[医药卫生—外科学]