阻塞性睡眠呼吸暂停综合征与脑卒中的相关性研究进展  

Advance in relationship between obstructive sleep apnea syndrome and stroke

作　　者：孙博 徐靖 孟自力[1] Sun Bo;Xu Jing;Meng Zili(Department of Respiratory and Critical Care Medicine,the Affiliated Huaian No.1 People′s Hospital of Nanjing Medical University,Huaian 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院呼吸与危重症医学科,淮安223300

出　　处：《国际呼吸杂志》2022年第11期813-817,共5页International Journal of Respiration

基　　金：国家自然科学基金(8190010427)。

摘　　要：阻塞性睡眠呼吸暂停综合征(OSAS)是一种与脑卒中有关的慢性疾病。脑卒中是全球发病率、致死率及致残率很高的疾病。OSAS是脑卒中的独立危险因素, 严重的OSAS可以导致脑卒中的发生, 脑卒中后也会出现OSAS, 二者之间相互影响。OSAS也会对脑卒中后其他事件, 如神经功能、认知功能等产生一定影响。持续气道正压通气是治疗OSAS目前最有效的方法, 但是该方法能否使OSAS后的脑卒中预后更好, 如在改善认知功能、神经功能, 提高生存率, 降低复发脑卒中等方面, 仍然有待讨论。本篇综述就OSAS对脑卒中的发生、复发、脑卒中后其他事件的影响及脑卒中后发生OSAS的治疗4个方面展开。Obstructive sleep apnea syndrome(OSAS)is a chronic disease associated with stroke.Stroke is featured with high morbidity,mortality and disability rate worldwide.Studies have shown that OSAS is an independent risk factor for stroke.Severe OSAS can lead to the occurrence and recurrence of stroke,OSAS and stroke interact with each other.OSAS can also affect other post-stroke events,such as neurological function and cognitive function.Continuous positive airway pressure(CPAP)is currently the most effective treatment for OSAS,but after OSAS whether CPAP therapy can achieve faster recovery or better prognosis regarding cognition and neurological function,survival rate,and stroke recurrence,and others remains to be discussed.This review aims to explore the impact of OSAS on 4 aspects of stroke epidemiology,stroke recurrence,post-stroke events,post-stroke OSAS therapy.

关 键 词：睡眠呼吸暂停 阻塞性 卒中 连续气道正压通气 复发性脑卒中 脑卒中后事件 

分 类 号：R766[医药卫生—耳鼻咽喉科] R743.3[医药卫生—临床医学]