阻塞性睡眠呼吸暂停不同病理生理特征动物模型评价方法  

Evaluation of pathophysiological phenotypes in animal models of obstructive sleep apnea

作　　者：刘海玲[1] 罗豫川 胡克[1] Liu Hailing;Luo Yuchuan;Hu Ke(Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,Chin)

机构地区：[1]武汉大学人民医院呼吸与危重症医学科,武汉430060

出　　处：《国际呼吸杂志》2022年第11期825-830,共6页International Journal of Respiration

基　　金：国家自然科学基金(81970082)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)是一种以睡眠期间反复发现上呼吸道阻塞为特征的疾病, 发病率高, 病理生理学机制复杂, 涉及上呼吸道解剖结构异常以及非解剖学因素两个方面, 后者包括上呼吸道神经肌肉反应性损害、呼吸控制不稳定(高环路增益)以及低觉醒阈值。动物模型是研究OSA病理生理特征的重要手段, 对于探讨OSA潜在药理学靶点也具有重要意义。本文介绍了基于OSA不同病理生理特征动物模型的评价方法。Obstructive sleep apnea(OSA)is a highly prevalent disease characterized by repeated obstruction of the upper airway during sleep.It has a complex pathophysiology involving abnormal upper airway anatomy and non-anatomical factors.Non-anatomical traits include a compromised neuromuscular response of the upper airway to obstruction,an unstable respiratory control(high loop gain),and a low arousal threshold.Animal models play important roles in studying pathophysiological traits of OSA and in identification of potential pharmacological targets on OSA.This article describes evaluation methods of animal model based on different pathophysiological features of OSA.

关 键 词：睡眠呼吸暂停 阻塞性 药物疗法 模型 动物 上呼吸道解剖 神经肌肉反应 环路增益 唤醒阈值 

分 类 号：R766[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]