陕西省特殊健康状态儿童预防接种评估门诊遗传代谢性肝病儿童预防接种研究  

Vaccination of children with hereditary metabolic liver disease in a vaccination evaluation clinic for children with special medical conditions in Shaanxi province

作　　者：彭晓康[1] 胡伟军[2] 陈艳妮[3] 李亚绒[1] 李小青[4] 李瑞娜[1] 舒畅 刘攀 刘希 唐丽 张少白[2] 刘小乖[1] Peng Xiaokang;Hu Weijun;Chen Yanni;Li Yarong;Li Xiaoqing;Li Ruina;Shu Chang;Liu Pan;Liu Xi;Tang Li;Zhang Shaobai;Liu Xiaoguai(Department of Infectious Diseases,Xi’an Children’s Hospital,Xi’an 710003,Shaanxi,China;Shaanxi Provincial Center for Disease Control and Prevention,Xi’an 710001,Shaanxi,China;Department of Child Health Care,Xi’an Children’s Hospital,Xi’an 710003,Shaanxi,China;Department of Rheumatology,Xi’an Children’s Hospital,Xi’an 710003,Shaanxi,China)

机构地区：[1]西安市儿童医院感染科,陕西西安710003 [2]陕西省疾病预防控制中心,陕西西安710001 [3]西安市儿童医院儿童保健科,陕西西安710003 [4]西安市儿童医院风湿免疫科,陕西西安710003

出　　处：《中国疫苗和免疫》2022年第3期317-323,共7页Chinese Journal of Vaccines and Immunization

基　　金：陕西省科技攻关项目(2016SF-135);西安市科技计划项目[2016052SF/YX08(3)];西安市卫生健康委员会科研项目(J201902036、2021yb30)。

摘　　要：目的探讨常见遗传代谢性肝病儿童的预防接种。方法选择2018-2021年西安市儿童医院就诊的5种遗传代谢性肝病患儿开展凝血功能、肝功能和/或免疫功能检查,进行预防接种评估和疫苗接种后不良反应随访,分析评估结果和不良反应发生率。结果共纳入1月龄-17岁遗传代谢性肝病儿童152例,其中高胆红素血症52例、希特林蛋白缺陷症33例、阿拉杰里综合症8例、肝豆状核变性51例、Ⅲ型糖原贮积症8例。经实验室检查和预防接种评估,建议接种灭活疫苗、接种减毒活疫苗、暂缓接种疫苗分别为142例(93.4%)、126例(82.9%)、10例(6.6%)。共接种15种疫苗1438剂次,发生不良反应4例(<38.5℃发热3例、局部硬结1例),总发生率为0.28%。结论常见遗传代谢性肝病儿童在病情稳定期可按免疫程序完成疫苗接种,不良反应少见且轻微。ObjectiveTo explore vaccination of children with common genetic metabolic liver diseases.MethodsWe selected children with any of 5 genetic metabolic liver diseases who visited Xi’an Children’s Hospital during 2018-2021 for coagulation, liver function, and/or immune function tests. We evaluated whether the children could be vaccinated and which vaccinations they should receive. We followed vaccinated children for adverse reactions. We analyzed with descriptive statistics the medical conditions,the vaccines given, and incidence of adverse reaction.ResultsA total of 152 children with hereditary metabolic liver disease who were between 1 month and 17 years old were enrolled in our vaccination evaluation clinic. There were 52 children with hyperbilirubinemia, 33 with Citrin deficiency, 8 with Alagille syndrome, 51 with Wilson’s disease, and 8 with type III glycogen storage disease. According to laboratory examinations and clinical evaluation of the appropriateness of vaccination, 142( 93. 4%)children were recommended to receive one or more inactivated vaccines;126( 82. 9%) were recommended for one or more live attenuated vaccines;and 10(6. 6%) children were recommended to delay vaccination. A total of 1 438 doses of 15 different vaccines were administered;4 adverse reactions occurred(3 were fever <38. 5℃ and 1 was local induration), for an overall incidence of 0. 28% adverse reactions per dose.ConclusionsChildren with common genetic metabolic liver disease in stable condition can receive vaccines in the routine immunization schedule. Adverse reactions after vaccination were rare and mild.

关 键 词：特殊健康状态 遗传代谢性肝病 预防接种 接种建议 不良反应 儿童 

分 类 号：R725.8[医药卫生—儿科]