tsRNAs的生物学功能及与疾病关系的研究进展  

Advances in the biological function of tsRNAs and its relationship with diseases

作　　者：任峻松 柏文 姚牧笛 赵雅 蒋沁[1] REN Jun-Song;BAI Wen;YAO Mu-Di;ZHAO Ya;JIANG Qin(The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属眼科医院,南京210029

出　　处：《生命科学》2022年第5期573-580,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81870679)。

摘　　要：tRNA衍生的小RNA(tRNA-derived small RNAs,tsRNAs)是一种来源于成熟tRNA或前体tRNA的非编码小RNA,广泛存在于多种物种中,主要分为tRNA衍生片段(tRNA-derived RNA fragments,tRFs)和tRNA半分子(t RNA halves,tiRNAs)两大类。近年来,随着生物信息学工具及RNA高通量测序技术的快速发展,tsRNAs的生物学功能以及在不同疾病病理生理中的作用被广泛研究,已成为非编码RNA领域的前沿热点。该文就tsRNAs的产生与分类、生物学功能,以及与疾病的关系和其潜在应用进行综述。tRNA-derived small RNAs(tsRNAs) is a kind of non-coding small RNAs derived from mature tRNA or pre-tRNA, and exists widely in many species. It is mainly divided into two categories: tRNA-derived fragments(tRFs) and tRNA halves(tiRNAs). In recent years, with the rapid development of bioinformatics tools and RNA high-throughput sequencing technology, the biological function of tsRNAs and its role in the pathophysiology of different diseases have been widely studied, which has become a research frontier hotspot in the field of non-coding RNA. This review focuses on the generation and classification of tsRNAs, the biological functions, the relationship with diseases and their potential application.

关 键 词：tsRNAs tRFs tiRNAs 生物学功能 疾病 

分 类 号：Q52[生物学—生物化学]