小口径人工血管的早期血栓形成与预防  

Early thrombosis and prevention of small-diameter blood vessel prosthesis

作　　者：史业弘 王成 陈世玖 Shi Yehong;Wang Cheng;Chen Shijiu(The Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Zhuhai 519100,Guangdong Province,China)

机构地区：[1]遵义医科大学第五附属(珠海)医院,广东省珠海市519100

出　　处：《中国组织工程研究》2023年第7期1110-1116,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81960842),项目负责人:王成。

摘　　要：背景:小口径人工血管在外周血管疾病治疗中有着广泛的应用价值,但因早期血栓形成导致移植失败的问题亟待解决。目的:总结小口径人工血管早期血栓形成与预防的研究进展。方法:由第一作者检索中国知网、万方、PubMed和Google Scholar数据库2000-2020年发表的相关文献,中文检索词为“小口径人工血管,小口径管状支架,组织工程血管,抗血栓,血栓形成,血液相容性,亲水性,内皮化”,英文检索关键词为“small-caliber vascular graft,vascular tissue engineering applications,endothelialization,hemocompatibility,surface modification”,检索国内外有关小口径人工血管血栓形成的病理生理机制及预防血栓形成的相关文献,就生物材料的表面改性和内皮化研究作为纳入标准,最终选取57篇文献进行综述。结果与结论:预防血栓形成是小口径人工血管研究的热点与难点,从近几年的国内外研究进展来看小口径人工血管早期血栓形成与血浆蛋白吸附、凝血因子的接触激活有关,通过提高表面亲水性、释放抗血栓物质、种植种子细胞、靶向基因诱导等方法,小口径人工血管血栓形成的状况得到一定程度改善,但当前仍处于试验阶段,距离临床应用尚有一定距离,仍需进一步探索或优化一种更适宜的血管材料,为临床应用提供更多选择。BACKGROUND:Small-diameter blood vessel prosthesis has a wide application value in the treatment of peripheral vascular diseases,but the problem of gratifailure due to early thrombosis needs to be solved.OBJECTIVE:To summarize research progress on early thrombosis and prevention of small-diameter blood vessel prosthesis.METHODS:The relevant literature published on CNKI,Wanfang,PubMed,and Google Scholar databases from 2000 to 2020 was retrieved by the first author.The Chinese search terms were“small-diameter blood vessel prosthesis,small-diameter tubular stents,tissue-engineered blood vessels,antithrombotic,thrombosis,hemocompatibility,hydrophilicity,endothelialization”.The English search terms were“small-caliber vascular grati,vascular tissue engineering applications,endothelialization,hemocompatibility,surface modification”.The relevant literature on the pathophysiological mechanism and prevention of small-diameter blood vessel prosthesis thrombosis in China and abroad was retrieved,and the surface modification and endothelialization of biological materials were taken as the inclusion criteria.Finally,57 articles were selected for review.RESULTS AND CONCLUSION:Prevention of thrombosis is a hotspot and a difficulty in the study of small-diameter blood vessel prosthesis.The research progress at home and abroad in recent years shows that the early thrombosis of small-diameter blood vessel prosthesis is related to plasma protein adsorption and contact activation of coagulation factors.By improving the surface hydrophilicity,releasing antithrombotic substances,planting seed cells and target gene induction,the thrombosis of small-diameter blood vessel prosthesis has been improved to a certain extent,but it is still in the experimental stage,and there is still a certain distance from clinical application.Therefore,it is necessary to further explore or optimize a more suitable vascular material to provide more choices for clinical application.

关 键 词：血管移植 小口径人工血管 血栓形成 血液相容性 表面改性 内皮化 组织工程 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1