纳米材料多模态显像示踪技术在间充质干细胞治疗尘肺中的应用  

Mesenchymal stem cell therapy for pneumoconiosis using nanomaterials combined with multi-modal molecular imaging

作　　者：薛婷 张新日[1] 孔晓梅[1] Xue Ting;Zhang Xinri;Kong Xiaomei(National Health Commission Key Laboratory of Pneumoconiosis,Key Laboratory of Prophylaxis and Treatment and Basic Research for Respiratory Diseases of Shanxi Province,Department of Respiratory and Critical Care Medicine,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]国家卫健委尘肺病重点实验室,呼吸疾病防治与基础研究山西省重点实验室,山西医科大学第一医院呼吸与危重症医学科,山西省太原市030001

出　　处：《中国组织工程研究》2023年第7期1133-1140,共8页Chinese Journal of Tissue Engineering Research

基　　金：山西省自然科学基金基础研究计划项目(20210302124039),项目负责人:薛婷;山西省高等学校科技创新项目(2020L0201),项目负责人:薛婷;山西医科大学省级博士基金项目(SD1905),项目负责人:薛婷;山西医科大学校级博士启动基金项目(XD1905),项目负责人:薛婷。

摘　　要：背景:临床前研究表明间充质干细胞可用于尘肺病的治疗,然而由于缺乏体内有效的间充质干细胞示踪技术,相关研究尚停滞于临床前探索,因此间充质干细胞示踪技术的发展是解决此问题的关键。目的:综述尘肺治疗现状、间充质干细胞治疗尘肺以及纳米材料多模态显像示踪技术在间充质干细胞治疗尘肺的研究进展,评价不同类型纳米材料多模态显像示踪技术在间充质干细胞治疗尘肺研究现状中的贡献、效果及前景,分析目前存在的问题及其未来的发展方向。方法:以PubMed为检索数据库,以“pneumoconiosis,pulmonary fibrosis,stem cells,MSCs,trace,nanoparticles,multi-modal imaging,therapy”为关键词进行检索,检索文献时限为2016-2021年,依据纳入和排除标准,最终纳入符合要求的60篇文献进行综述。结果与结论:①目前的临床前研究显示,金纳米颗粒、磁靶向纳米颗粒及近红外长余辉发光纳米颗粒3种材料设计精巧且新颖,具有良好的生物相容性、稳定性、安全性和多模态成像能力等优点,在间充质干细胞治疗尘肺过程中体内示踪及发挥抗肺纤维化作用疗效评价的临床前应用初显成效,示踪长效性、靶向定位、余辉光学性能顺次分别是上述3种纳米材料的优势。②金纳米颗粒是纳米材料联合多模态显像示踪技术在间充质干细胞治疗尘肺的临床应用中最具应用前景的纳米材料,很大程度上推动了间充质干细胞治疗尘肺领域的进展与临床转化。③纳米材料多模态显像示踪的研究为实现间充质干细胞治疗尘肺的临床应用提供了可靠的新技术,对进一步推进靶向治疗尘肺的临床转化应用与实践具有重要的意义。④在精准医疗引领的新时代,阐明间充质干细胞治疗尘肺机制,解决增强纳米材料标记间充质干细胞的靶向积累、提高间充质干细胞摄取和控制缓释效力、延长药物半衰期以及维持稳BACKGROUND:Previous studies indicate that mesenchymal stem cells are used for therapy of pneumoconiosis.However,related studies are still at the stage of preclinical research due to a lack of effective tracing techniques in vivo for mesenchymal stem cells.Therefore,these effective tracing techniques in vivo for stem cells are the key to solve it.OBJECTIVE:To review the research progresses of present therapy situations for pneumoconiosis,related studies on mesenchymal stem cell therapy for pneumoconiosis and different nanoparticles combined with multi-modal molecular imaging in mesenchymal stem cell therapy for pneumoconiosis,evaluate the contribution,effect and prospect of different types of nanomaterials multi-modal imaging tracking technology in the research status of mesenchymal stem cell therapy for pneumoconiosis,and analyze the present problems and future development directions.METHODS:PubMed database was searched for articles published from 2016 to 2021.Key words were“pneumoconiosis,pulmonary fibrosis,stem cells,MSCs,trace,nanoparticles,multi-modal imaging,therapy”.According to the inclusion and exclusion criteria,60 relevant articles were finally included for review.RESULTS AND CONCLUSION:(1)Preclinical studies indicate that gold nanoparticles,magnetic nanoparticles and near-infrared-long persistent luminescence nanoparticles are innovative and ingenious in design with a series of advantages such as biocompatibility,stability,safety and capabilities of multi-modal imaging.Initial effectiveness is achieved in preclinical applications of in vivo tracking and anti-fibrosis therapeutic evaluation in the process of anti-pulmonary fibrosis treatment of mesenchymal stem cells.Meanwhile,each nanoparticle has its own advantages,for instance,long-term in vivo tracking,targeting special localization and long persistent luminescence respectively are merits of the gold nanoparticles,magnetic nanoparticles and near-infrared-long persistent luminescence nanoparticles.(2)Gold nanoparticles are the most promising nano

关 键 词：尘肺 肺纤维化 干细胞 间充质干细胞 示踪 纳米材料 多模态显像 治疗 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学] R686.5