探讨阿昔莫司联合阿托伐他汀钙片治疗高脂血症的疗效  

To investigate the efficacy of acipimox combined with atorvastatin calcium tablets on hyperlipidemia

作　　者：沈冲[1] 陆强[1] 高德全[1] 王乐丰[2] SHEN Chong;LU Qiang;GAO Dequan;WANG Lefeng(Department of Cardiology,Liangxiang Hospital,Fangshan District,Beijing 102401;Department of Cardiology,Section 3,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]北京市房山区良乡医院心血管内科,102401 [2]首都医科大学附属北京朝阳医院心血管内科3病区,100020

出　　处：《中国老年保健医学》2022年第3期59-61,共3页Chinese Journal of Geriatric Care

摘　　要：目的 研究高脂血症合并颈动脉斑块患者采取阿昔莫司联合阿托伐他汀钙片治疗的效果,为该类患者的治疗提供理论依据。方法 研究对象为2018年6月至2019年6月在我院治疗的高脂血症并颈动脉斑块患者78例,将其随机分为阿托伐他汀钙片组(对照组,39例)和阿昔莫司+阿托伐他汀钙片组(试验组,39例)。对照组给予阿托伐他汀钙片20mg,口服,每晚1次;试验组给予阿昔莫司0.25g,口服,每日3次;阿托伐他汀钙片20mg,口服,每晚1次。两组患者的疗程都是8周,观察两组患者治疗前后血脂水平、颈动脉内膜中层厚度(IMT)、颈动脉斑块面积、硬化斑块指数(AI)。结果 治疗前两组患者血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、IMT、颈动脉斑块面积、AI比较,差异均无统计学意义(P>0.05);治疗后两组患者TC、TG、LDL-C、IMT、颈动脉斑块面积、AI均明显降低,且试验组显著低于对照组(P<0.05)。治疗后两组患者HDL-C水平明显提升,且试验组高于对照组(P<0.05)。结论 阿昔莫司联合阿托伐他汀钙片治疗高脂血症可有效改善患者病情,保障其身体健康,此治疗方案相比于单用阿托伐他汀治疗更具优势,更适宜在临床中推广应用。Objective To study the effect of acipimox combined with atorvastatin in patients with hyperlipidemia and carotid plaque and provide theoretical basis for the treatment of such patients.Methods The 78 patients with hyperlipidemia and carotid plaque treated in our hospital from June 2018 to June 2019 were randomized into atorvastatin calcium tablet group(control group,39 cases)and acipimox plus atorvastatin calcium tablet group(trial group,39 patients).The control group was given 20mg of atorvastatin calcium tablets,orally,once per night,the test group administered 0.25 g orally,three times daily;and 20mg orally,once per night.The course of group two patients was 8 weeks,and blood lipid levels,carotid intimal thickness(IMT),carotid plaque area,and hardened plaque index(AI)were observed in group 2 patients before and after treatment.Results Total plasma cholesterol(TC),triglyceride(TG),LDL cholesterol(LDL-C),HDL-C,high DL cholesterol,IMT,carotid plaque area,AI were not significant(P>0.05);TC,TG,LDL-C,IMT,carotid plaque area and AI were significantly lower than the control group(P<0.05).After treatment,the HDL-C levels were significantly increased,and the trial group was higher than the control group(P<0.05).Conclusion Acipimox combined with atorvastatin can improve the condition and ensure their health.This treatment scheme is more advantageous and suitable for atorvastatin in clinical practice.

关 键 词：阿昔莫司 阿托伐他汀钙片 高脂血症 颈动脉斑块 

分 类 号：R589.2[医药卫生—内分泌]